Sentences with word «luminal»

Previous work led by Charlotte Kuperwasser, principal investigator, determined that some common forms of breast cancer originate from luminal cells while some rarer forms of breast cancer originate from basal cells.

Notably, in mice bearing breast cancer cell line - derived tumors, administration of OTSSP167 significantly impaired the growth of basal breast tumors, or even caused tumor regression; by contrast, the growth of luminal tumors were largely unaffected by the treatment (Figure 7E, 7F).

They found that a small number of genes are activated by STAT3 protein signaling in basal - like breast cancers but not in luminal breast cancers.

Dr Feng found that a small RNA, often called microRNA, is lost in highly metastatic TNBC cells but not in luminal breast cancer.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Remarkably, down - regulation of MELK led to a substantial regression of tumors arising from BBC cells but had little effect on tumors derived from luminal cancer cells (Figure 7C, D, Figure 7 — figure supplement 1).

A subgroup of predominantly luminal A cases with low genomic instability that was enriched for histology types with good prognoses (e.g. lobular and tubular carcinomas).

Research has revealed that omega - 3 fatty acids are more effective in stopping or slowing the growth in the number of triple - negative breast cancer cells in comparison to cells from luminal categories of breast cancer.

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

Blind loops are very uncommon in small animal gastroenterology but overgrowth probably occurs when partial obstructions in dogs and cats cause luminal contents to stagnate.

Surprisingly and in sharp contrast with the common thought, which hypothesized the existence of a population of common progenitors that give rise to ER + and ER - cells, Alexandra Van Keymeulen and colleagues found that the ER + lineage is maintained by a lineage restricted ER + luminal stem cells, able to ensure ER + lineage expansion during pubertal development, and long - term renewing capacities of ER + lineage in adult mice during cycle of pregnancy - involution.

Even more striking is the finding that only basal - like, but not luminal breast cancer cells, depend on MELK for proliferation.

Both of these subtypes are estrogen receptor (ER) positive, with luminal A carrying the most favorable prognosis.

In breast tissue from women with cancer, they found high levels of TAZ in basal but not luminal tumors.

In addition, the tumor was positive for estrogen receptor alpha (ER alpha) and cell proliferation marker Ki67, and negative for receptor tyrosine kinase HER2 / ErbB2, suggesting that it has features like luminal B type breast cancer in humans.

In a final experiment, Dr. Kirino and colleagues also examined clinical samples from breast cancer patients and found elevated levels of SHOT - RNAs in patients with ER - positive luminal - type cancers, but not those that were negative for ER expression.

Genetically altering lab mice, they made sure the gene known to cause luminal - like breast cancer was present but they also inactivated the cyclin D1.

Cells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC state.

Resulting increases in permeability allow for luminal factors (intestinal contents) to access the immune system and to set off autoimmune and inflammatory processes.

Hyper Luminal Games are a wee independent games studio based in Dundee, Scotland.

Hyper Luminal Games are also planning to release the game on the Nintendo Switch in Q1 2019.

While luminal cells secrete water and nutriments to produce the milk during lactation, the basal cells, through their contraction, guide the circulation of the milk throughout the ductal tree.

Coronary angiography demonstrated minor luminal irregularities without significant stenosis.

Human breast cancers can be classified according to their histological and molecular features into different subtypes, including luminal, ERBB2 and basal - like tumors.

Phenobarbital, a long - acting barbiturate introduced in 1912 under the trade name Luminal, was initially marketed for sedation and to induce sleep.

The research team found that the experimental group had an imbalance of cell populations in breast tissue: too many luminal and too few basal.

Normally luminal cells are «programmed» by a particular class of proteins (transcription factors), which prevent them from becoming basal cells, and vice-versa.

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

Additional insight into the biology of ER - positive breast cancers, particularly the higher risk luminal B cancers, could aid in identifying potential targets and new, effective therapies.

Animal microbiome Spatial Heterogeneity and Co-occurrence of Mucosal and Luminal Microbiome across Swine Intestinal Tract.

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Patients with basal breast cancer generally have a poorer prognosis than those with the less aggressive luminal - type breast cancer.

EPCs were then detached from luminal wall using 1 mg / ml collagenase (Sigma, St. Louis, MO) as static incubation at 37 °C for 15 to 20 min after clipping both ends of the blood vessel.

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).

If this surface breaks down, your immune system will get activated and start reacting to foods, toxins, and bugs in your gut [luminal contents].

According to Rapin and Wiernsperger (2010), «Tight junctions play a major role in regulating the paracellular passage of luminal elements» (p. 635).

«Among the several potential intestinal luminal stimuli that can trigger zonulin release, we identified small intestinal exposure to bacteria and gluten as the two more powerful triggers.

Thus the «forgotten organ» of the gastrointestinal microbiota is a prime candidate to be influenced by evolutionarily unprecedented postprandial luminal carbohydrate concentrations.

The presence of luminal nutrition is thought to help maintain the integrity of the gastrointestinal mucosa and promote healthier motility, leading to less vomiting.