Sentences with phrase «luminal a»

Oscar for Meaning - Making: The Lovely Bones: After a zestful adolescent girl is murdered, she goes to a luminal, in - between place in which she fails to let go and struggles in vain to help her family cope with the loss.

Solar cycles of magnetic variability result in changes in the luminal spectra of the sun, the properties of the solar wind, and the flux of galactic cosmic rays incident on Earth's atmosphere.

Luminal Schema · Luminous Lint · Joanne Mattera · Modern Art Obsession · Modern Art Notes · Modern Kicks.

Lucy Skaer's work occupies a luminal space, a gap, beyond the literal and the symbolic.

Through geographic and chronological investigation of human experiences and material cultures, Tang creates luminal areas to recontextualize and compare systems of cultures in his multi-disciplinary artistic production that include video, sound, and graphic and sculptural installation.

His site - specific constructed installations investigate non-objective abstraction and perceptual qualities in constructed environments that reconstructs architectural space in a blend of minimalism, process art and kinaesthetic experience that incorporates immersive light, sensory perception and luminal effects of uniform light (Ganzfelds).

Hyper Luminal Games are also planning to release the game on the Nintendo Switch in Q1 2019.

The efficiency of the large intestine for dehydrating the luminal contents is dependent on close coordination between colonic motility and absorptive functions (Rolfe 1999; Rolfe et al. 2002a).

Proposed causes for human IBD include defective immunoregulation of the gut - associated lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.

P - glycoprotein is present on the luminal border of these intestinal epithelial cells where it transports drugs from the cytoplasm back into the intestinal lumen where they can be eliminated.

The use of soluble (fermentable) fiber in preference to insoluble (non-fermentable) fiber is sometimes advocated because most soluble fibers generate butyrate, the principle source of energy for the colonocyte, and other short - chain fatty acids.23 Short - chain fatty acids may lower the colonic luminal pH, impeding the growth of pathogens.23 The use of dietary fiber can have deleterious consequences.

The presence of luminal nutrition is thought to help maintain the integrity of the gastrointestinal mucosa and promote healthier motility, leading to less vomiting.

Blind loops are very uncommon in small animal gastroenterology but overgrowth probably occurs when partial obstructions in dogs and cats cause luminal contents to stagnate.

I'll be looking to change a color and something comes up on the screen, like a luminal phase between a green and a red.

Thus the «forgotten organ» of the gastrointestinal microbiota is a prime candidate to be influenced by evolutionarily unprecedented postprandial luminal carbohydrate concentrations.

In addition, curcumin significantly improves barrier function, reducing translocation of lipopolysaccharide (LPS), the outer cell wall of gram - negative bacteria, from the luminal surface of the intestine into circulation (Ghosh et al., 2014).

«Among the several potential intestinal luminal stimuli that can trigger zonulin release, we identified small intestinal exposure to bacteria and gluten as the two more powerful triggers.

Between Celiac Disease and Irritable Bowel Syndrome: The «No Man's Land» of Gluten Sensitivity https://www.nature.com/articles/ajg2009188 «We discuss the hypothesis that GS and post-infectious irritable bowel syndrome (IBS) provide two triggers that can explain at least part of the spectrum that constitutes IBS, further advancing an understanding of the role of mucosal responses to luminal factors in FBDs.»

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

According to Rapin and Wiernsperger (2010), «Tight junctions play a major role in regulating the paracellular passage of luminal elements» (p. 635).

Summarized by Suzuki (2013), «Disruption of the intestinal tight junction barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases» (p. 631).

If this surface breaks down, your immune system will get activated and start reacting to foods, toxins, and bugs in your gut [luminal contents].

GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation of luminal antigens, or sometimes provoking damage to the intestinal mucosa, such as in coeliac disease or food allergy.

Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.

Resulting increases in permeability allow for luminal factors (intestinal contents) to access the immune system and to set off autoimmune and inflammatory processes.

Research has revealed that omega - 3 fatty acids are more effective in stopping or slowing the growth in the number of triple - negative breast cancer cells in comparison to cells from luminal categories of breast cancer.

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

Reviewer # 1 also had concerns that the degree of knockdown of MELK by shMELK in the basal cell lines appears stronger than in the luminal cell lines, equivalent knockdown needs to be demonstrated by both quantitative protein and mRNA analysis.

Mammary progenitors identified by a new marker, ICAM - 1, undergo epithelial - mesenchymal transition and luminal - to - basal switch in response to paracrine Met activation.

It could be that the degree of knockdown of MELK in the luminal cell lines did not go below a necessary threshold to cause a proliferation effect.

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

Remarkably, down - regulation of MELK led to a substantial regression of tumors arising from BBC cells but had little effect on tumors derived from luminal cancer cells (Figure 7C, D, Figure 7 — figure supplement 1).

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

As our aim was to indicate general tissue specific carcinogenic properties, we used all the known subtypes of these cancers, including (1) hyper mutated and non-hypermutated colon cancers; (2) lung adenocarcinomas, large cell carcinomas, and squamous cell carcinomas (3) HER2 positive, basal, luminal A and luminal B breast cancers; and (4) hepatitis B or hepatitis C, cirrhosis or other agent causing hepatocellular carcinoma data.

(C and D) Effects of MELK knockdown on established tumors arising from implantation of basal (C) or luminal (D) breast cancer cells.

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.

This luminal progenitor compartment undergoes transcriptional changes in response to a full pregnancy, lactation and involution.

Primary kidney epithelial cells isolated from human proximal tubule are cultured on the upper surface of an extracellular matrix - coated, porous, polyester membrane that splits the main channel of the device into two adjacent channels, thereby creating an apical «luminal» channel and a basal «interstitial» space.

We argue instead that the epithelial cells - especially in the luminal compartment - should rather be conceptualised as being part of a continuous spectrum of differentiation.

The percent area covered by blood platelets over the luminal surface of untreated or treated ePTFE tubings was calculated by calculating the percent area covered by CD41 (platelets marker) using binary image processing on Zeiss LSM Image Examiner software.

Furthermore, our data support the existence of a common luminal progenitor cell giving rise to intermediate, restricted alveolar and hormone - sensing progenitors.

, van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Patients with basal breast cancer generally have a poorer prognosis than those with the less aggressive luminal - type breast cancer.

Cells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC state.

Title: Developmental stage - specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland Authors: de Visser KE, Ciampricotti M, Michalak EM, Wei - Min Tan D, Speksnijder EN, Hau C - S, Clevers H, Barker N, Jonkers J Date: 2012 Publication Details: The Journal of Pathology 2011 May; 224 (1): 56 - 66

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

ER - positive tumors comprise two «intrinsic subtypes»: Luminal A, which generally has a favorable prognosis, and Luminal B, which generally has a worse prognosis.