Sentences with phrase «luminal breast»

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.

Cells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC state.

Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

Not exact matches

Human breast cancers can be classified according to their histological and molecular features into different subtypes, including luminal, ERBB2 and basal - like tumors.

The research team found that the experimental group had an imbalance of cell populations in breast tissue: too many luminal and too few basal.

Previous work led by Charlotte Kuperwasser, principal investigator, determined that some common forms of breast cancer originate from luminal cells while some rarer forms of breast cancer originate from basal cells.

In breast tissue, there are two main types of cells: luminal cells and basal cells.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

«The luminal progenitors we have found to possess this feature are thus now being brought into the spotlight as a likely stage where breast cancer may «take off.»»

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

The Cancer Genome Atlas study encompasses more than 500 primary tumors representing the four intrinsic subtypes of breast cancer: Luminal A, Luminal B, Her2 - enriched, and Basal - like.

Figure 5 shows how key pathways are altered in luminal (first % box) and basal (middle box) breast cancer and ovarian cancer (right box).

The observed mutation rate in coding regions seems to reflect the aggressiveness of breast cancer subtypes: lower in luminal A (0.84 mutations / Mbp) than luminal B (1.36 mutations / Mbp), higher in Her2 - enriched (2.05 mutations / Mbp) and Basal - like (1.68).

Genetically altering lab mice, they made sure the gene known to cause luminal - like breast cancer was present but they also inactivated the cyclin D1.

Additional insight into the biology of ER - positive breast cancers, particularly the higher risk luminal B cancers, could aid in identifying potential targets and new, effective therapies.

The Tufts team discovered that luminal - like breast cancers (the two most common types, and which are sensitive to hormones) originate from self - renewing cells known as lobule progenitors.

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Patients with basal breast cancer generally have a poorer prognosis than those with the less aggressive luminal - type breast cancer.

(C and D) Effects of MELK knockdown on established tumors arising from implantation of basal (C) or luminal (D) breast cancer cells.

As our aim was to indicate general tissue specific carcinogenic properties, we used all the known subtypes of these cancers, including (1) hyper mutated and non-hypermutated colon cancers; (2) lung adenocarcinomas, large cell carcinomas, and squamous cell carcinomas (3) HER2 positive, basal, luminal A and luminal B breast cancers; and (4) hepatitis B or hepatitis C, cirrhosis or other agent causing hepatocellular carcinoma data.

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).

Research has revealed that omega - 3 fatty acids are more effective in stopping or slowing the growth in the number of triple - negative breast cancer cells in comparison to cells from luminal categories of breast cancer.