Sentences with phrase «luminal cells»

This interaction causes the myoepithelial cells — on the outer layer of the ductal structure — to contract, squeezing the luminal cells within.

In breast tissue, there are two main types of cells: luminal cells and basal cells.

Previous work led by Charlotte Kuperwasser, principal investigator, determined that some common forms of breast cancer originate from luminal cells while some rarer forms of breast cancer originate from basal cells.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

The luminal cells generally lead to more aggressive tumors.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Luminal cells can be subdivided into estrogen (ER) / progesterone (PR) positive and negative cells.

It could be that the degree of knockdown of MELK in the luminal cell lines did not go below a necessary threshold to cause a proliferation effect.

Reviewer # 1 also had concerns that the degree of knockdown of MELK by shMELK in the basal cell lines appears stronger than in the luminal cell lines, equivalent knockdown needs to be demonstrated by both quantitative protein and mRNA analysis.

Not exact matches

The control group had a normal ratio of luminal to basal cells.

The research team found that the experimental group had an imbalance of cell populations in breast tissue: too many luminal and too few basal.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

The Tufts team discovered that luminal - like breast cancers (the two most common types, and which are sensitive to hormones) originate from self - renewing cells known as lobule progenitors.

Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

Title: Developmental stage - specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland Authors: de Visser KE, Ciampricotti M, Michalak EM, Wei - Min Tan D, Speksnijder EN, Hau C - S, Clevers H, Barker N, Jonkers J Date: 2012 Publication Details: The Journal of Pathology 2011 May; 224 (1): 56 - 66

Cells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC sCells from basal cancers are able to switch relatively easily into cancer stem cell (CSC) state, unlike luminal breast cancer cells, which tend to remain in the non-CSC scells, which tend to remain in the non-CSC state.

, van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Furthermore, our data support the existence of a common luminal progenitor cell giving rise to intermediate, restricted alveolar and hormone - sensing progenitors.

We argue instead that the epithelial cells - especially in the luminal compartment - should rather be conceptualised as being part of a continuous spectrum of differentiation.

Primary kidney epithelial cells isolated from human proximal tubule are cultured on the upper surface of an extracellular matrix - coated, porous, polyester membrane that splits the main channel of the device into two adjacent channels, thereby creating an apical «luminal» channel and a basal «interstitial» space.

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.

(C and D) Effects of MELK knockdown on established tumors arising from implantation of basal (C) or luminal (D) breast cancer cells.

As our aim was to indicate general tissue specific carcinogenic properties, we used all the known subtypes of these cancers, including (1) hyper mutated and non-hypermutated colon cancers; (2) lung adenocarcinomas, large cell carcinomas, and squamous cell carcinomas (3) HER2 positive, basal, luminal A and luminal B breast cancers; and (4) hepatitis B or hepatitis C, cirrhosis or other agent causing hepatocellular carcinoma data.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

Remarkably, down - regulation of MELK led to a substantial regression of tumors arising from BBC cells but had little effect on tumors derived from luminal cancer cells (Figure 7C, D, Figure 7 — figure supplement 1).

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

Research has revealed that omega - 3 fatty acids are more effective in stopping or slowing the growth in the number of triple - negative breast cancer cells in comparison to cells from luminal categories of breast cancer.

In addition, curcumin significantly improves barrier function, reducing translocation of lipopolysaccharide (LPS), the outer cell wall of gram - negative bacteria, from the luminal surface of the intestine into circulation (Ghosh et al., 2014).

P - glycoprotein is present on the luminal border of these intestinal epithelial cells where it transports drugs from the cytoplasm back into the intestinal lumen where they can be eliminated.