Sentences with phrase «luminal tumors»

Not exact matches

Human breast cancers can be classified according to their histological and molecular features into different subtypes, including luminal, ERBB2 and basal - like tumors.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

The luminal cells generally lead to more aggressive tumors.

The team also looked at the levels of the TAZ gene in tumors from women with either luminal or basal tumors.

Horvath and Tell identified 84 genes that are expressed differently in basal - like cancer tumors as compared to luminal cancer tumors.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

The Cancer Genome Atlas study encompasses more than 500 primary tumors representing the four intrinsic subtypes of breast cancer: Luminal A, Luminal B, Her2 - enriched, and Basal - like.

Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B luminal B (24 %).

ER - positive tumors comprise two «intrinsic subtypes»: Luminal A, which generally has a favorable prognosis, and Luminal B, which generally has a worse prognosis.

(C and D) Effects of MELK knockdown on established tumors arising from implantation of basal (C) or luminal (D) breast cancer cells.

Remarkably, down - regulation of MELK led to a substantial regression of tumors arising from BBC cells but had little effect on tumors derived from luminal cancer cells (Figure 7C, D, Figure 7 — figure supplement 1).

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).