First up was Peter Campbell from Wellcome Trust Sanger Institute, who presented their first cancer genome — a small
lung cancer cell line called NCI - H209.
(a kinase implicated in several human cancers) in A549 cells (a human
lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).
I wanted to inactivate the gene BRAF (a kinase implicated in several human cancers) in A549 cells (a human
lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).
Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapy in the A549 non-small-cell
lung cancer cell line.
... In
lung cancer cell lines, CBD upregulated ICAM - 1, leading to...
They found out that TiY is capable of distinguishing TICs from non-TICs in various human
lung cancer cell lines and patient - derived lung tumors.
«Our study results suggest a new drug cocktail that is effective in both human
lung cancer cell lines and fly models,» says Cagan.
Using both fruit fly and human
lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).
In tests on EGFR - dependent
lung cancer cell lines, Tan and colleagues show that the drugs gefitinib and bosutinib «showed additive and synergistic effects.»
Treatment of
lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.
We screened the coding sequences of 518 protein kinases (approximately 1.3 Mb of DNA per sample) for somatic mutations in 26 primary lung neoplasms and seven
lung cancer cell lines.
Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small cell
lung cancer cell lines.
33) Gandhi J, Zhang J, Xie Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Garcia M, Minna JD, Gazdar AF (2009) Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in
lung cancer cell lines.
42) Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) High resolution analysis of non-small cell
lung cancer cell lines by whole genome tiling path array CGH.
Researchers tested the effects of CBD, THC, and an endocannabinoid analogue called methanandamide on two
lung cancer cell lines, A549 and H460, along with cells from a lung cancer patient.
Not exact matches
The
cell lines were actually
lung, colon and stomach
cancers.
Beyond
lung cancer, TiY is able to target TICs in 28 types of human
cell lines derived from the central nervous system, melanoma, breast, renal, ovarian, colon, and prostate
cancer.
Nana - Sinkam and his colleagues examined
lung - tumor samples from 81 patients with stage - 1 nonsmall -
cell lung cancer and tumor -
cell lines.
To determine whether endothelial
cells — the
cells that
line the interior surface of blood vessels — directly influence breast
cancer cell growth, they then created unique organotypic models of
lung and bone marrow microvascular niches, in which endothelial
cells formed blood vessel - like structures in culture as they would in the original organ.
«Patients with non-small
cell lung cancer (NSCLC) should receive front
line therapy with the anaplastic lymphoma kinase (ALK) inhibitor crizotinib,» said lead author Professor Giorgio Scagliotti, head of the Department of Oncology, University of Turin, Italy.
Knowing more about the activation process has led researchers to be able to induce greater vulnerability by
cancer cells to an existing first -
line treatment for
cancers (mainly
lung) driven by a receptor called EGFR.
Phase II / III Biomarker - Driven Master Protocol for Second
Line Therapy of Squamous
Cell Lung Cancer
$ 1.8 M Supports
Cancer Drug Discovery on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric Stem
Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian
Cancer GMNews.com - March 2, 2016 Differences in Type of Small Protein may further Elucidate
Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate
Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the
Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the
Lung Cancer Ribbon?
Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second -
line therapy of small
cell lung cancer (NCI # 7097).
With the recent announcement that a first -
line immunotherapy trial for non-small
cell lung cancer (NSCLC) is positive for survival improvement, I can see the standard of care for
lung cancer patients radically changing over the next few years.
Along the same
lines, in non-small
cell lung cancer (NSCLC), acquired resistance to Gefitinib / Erlotinib kinase inhibitors has also been associated with a secondary mutation of the gatekeeper Thr790 residue of the epidermal growth factor receptor (EGFR).
The 1833 (bone metastasis), 4175 (
lung metastasis), and BrM2a (brain metastasis) sublines were derived from the parental
cell line MDA - MB - 231 (19) and were gifts from J. Massague (Memorial Sloan - Kettering
Cancer Center).
«The TAILOR study draws out attention to the fact that outcomes are poor in second -
line treatment of non — small -
cell lung cancer, with our available treatments resulting in median progression - free survivals of two or three months,» said Benjamin Solomon, MBBS, PhD, of Peter MacCallum Cancer Centre in Melb
cancer, with our available treatments resulting in median progression - free survivals of two or three months,» said Benjamin Solomon, MBBS, PhD, of Peter MacCallum
Cancer Centre in Melb
Cancer Centre in Melbourne.
Merck's
cancer drug Keytruda got the nod of U.S. regulators as a first -
line drug for treating metastatic non-small
cell lung cancer.
Red foods like red bell peppers and tomatoes contain a phytochemical called lycopene, which may have an anti-inflammatory affect on the
cells lining the heart and blood vessels, and may reduce the risk of developing prostate
cancer among other
cancers such as breast,
lung, bladder, ovarian, and colon.
This drug is indicated in combination with Cisplatin (a chemotherapeutic drug) for the first -
line treatment of patients with inoperable, locally advanced, or metastatic non-small
cell lung cancer.