They found out that TiY is capable of distinguishing TICs from non-TICs in various
human lung cancer cell lines and patient - derived lung tumors.
42) Garnis C, Lockwood WW, Vucic E, Ge Y, Girard L, Minna JD, Gazdar AF, Lam S, MacAulay C, Lam WL (2006) High resolution analysis of non-small
cell lung cancer cell lines by whole genome tiling path array CGH.
33) Gandhi J, Zhang J, Xie Y, Shigematsu H, Soh J, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Garcia M, Minna JD, Gazdar AF (2009) Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity
in lung cancer cell lines.
First up was Peter Campbell from Wellcome Trust Sanger Institute, who presented their first cancer genome — a
small lung cancer cell line called NCI - H209.
Treatment
of lung cancer cell lines with mebendazole caused mitotic arrest by depolymerization of tubulin, followed by apoptotic cell death.
They infected a non-small cell
lung cancer cell line containing an activating mutation in epidermal growth factor receptor (EGFR) with the ClonTracer library and monitored population dynamics after treatment with EGFR inhibitor, erlotinib.
28) Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD (2010)
Lung cancer cell lines as tools for biomedical discovery and research.
Using both fruit fly and human
lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).
If an easier alternative were available, most researchers would use it, says Neville Sanjana, a core faculty member at NYGC and assistant professor at NYU's Department of Biology who works on skin and
lung cancer cell lines and was not involved in the study.
We screened the coding sequences of 518 protein kinases (approximately 1.3 Mb of DNA per sample) for somatic mutations in 26 primary lung neoplasms and seven
lung cancer cell lines.
I wanted to inactivate the gene BRAF (a kinase implicated in several human cancers) in A549 cells (a human
lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).
(a kinase implicated in several human cancers) in A549 cells (a human
lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).
Shapiro GI, Koestner DA, Matranga CB, et al: Flavopiridol induces cell cycle arrest and p53 - independent apoptosis in non-small cell
lung cancer cell lines.
Researchers tested the effects of CBD, THC, and an endocannabinoid analogue called methanandamide on two
lung cancer cell lines, A549 and H460, along with cells from a lung cancer patient.