Creating
human lung epithelial cells in the lab has been a challenge, and lineage - specific reporters, which indicate each cell's specific type, are key to understanding lung epithelial stem cell development.
The Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center has engineered two new categories
of lung epithelial cells in vitro using pluripotent stem cells.
Kang found Korean red ginseng extract improved the survival of human
lung epithelial cells against RSV infection and inhibited the virus from replicating, or multiplying, in the body.
She examined the response
of lung epithelial cells to fluids used in vaping, a practice often promoted as a safer alternative to smoking cigarettes.
Working in
human lung epithelial cells, researchers used a variety of techniques to show that flu infection increased activity of the PI3K and mTOR pathways and that BEZ235 restored PI3K and mTOR activity to pre-infection levels.
Human
lung epithelial cells and human embryonic kidney cells were exposed to several viruses, Ebola virus, Marburg virus, vesicular stomatitis virus and Zika virus, and the antiviral effects of the three chemical structures were observed.
Researchers showed that flu infection changed the metabolism of human
lung epithelial cells, the prime location for replication of flu virus.
The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human
lung epithelial cells.
«Previously, little was known about how flu infection changed the metabolism of
lung epithelial cells; but based on early evidence in this study we suspected metabolism was an Achilles heel of the virus,» said corresponding author Paul Thomas, Ph.D., an associate member of the St. Jude Department of Immunology.
«Cell aging in
lung epithelial cells.»
Adenosine induces fibronectin expression in
lung epithelial cells: implications for airway remodeling.
The TNF family molecules LIGHT and lymphotoxin ab induce a distinct steroid - resistant inflammatory phenotype in human
lung epithelial cells.
Calcitonin gene - related peptide (CGRP) has been shown to improve survival of
lung epithelial cells and reduce hyperoxic lung injury in rats.
A recent in vitro study revealed that exposure of
lung epithelial cells to E-cig-conditioned medium induces a gene expression signature similar to tobacco smoke [11].
American Journal of Physiology, Lung Cellular and Molecular Physiology, 294 (3): L478ï ¿ 1/2 88, «Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke - mediated oxidative stress in human
lung epithelial cells».