Sentences with phrase «lung function at»

«If it were possible to repeat lung function at one time only, the best time would be around age 25, when lung growth peaks.»

«Children who had low lung function at the start of the trial followed a series of predicted growth patterns: most had reduced lung growth with time and a significant number would go on to meet the criteria for COPD.»

In addition to low lung function at the start of the study, being male also predicted worse outcomes, but this is likely a consequence of higher asthma prevalence in boys.

However, there was no significant evidence of an association between early postnatal life (during the first year of life), recent and current exposures to outdoor air pollutants with lung function at preschool age.

He's going to be requiring quite a bit more medical care, numerous check - ups to monitor his progress, and meds for life to keep his lungs functioning at their best capacity.

Not exact matches

In general, most babies born at 35 weeks will have adequate functioning lungs and babies have traditionally been considered «full - term» with normally - developed lungs by 37 weeks.

Although at this time, lung surfactants, which aid in lung expansion after the birth of the baby, is already present, the lungs are still very immature to function properly like sending out oxygen to the bloodstream during inhalation and releasing carbon dioxide during exhalation.

All necessary body functions are working perfectly, time spent in the uterus at this point is all about lung development and weight gain.

Researchers are looking at delays or abnormalities in brain development of nerve cells that are responsible for heart and lung function.

Right now, as your baby is preparing to live outside of your body, she's developing at a rapid pace: Her lungs and kidneys are growing stronger so that they can take over the functions that yours are now performing, and her brain is quickly maturing.

«The results supply the foundation for detailed research into lung diseases and clarification of the association between genetics, lung function and susceptibility to respiratory disorders,» reports Prof. Dr. Holger Schulz, head of the Pulmonary Epidemiology research group at the Helmholtz Zentrum München (HMGU).

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

From the 1,295 women enrolled in the study at the beginning of pregnancy, the researchers obtained data on exposure to both air pollution and lung function assessment at 4.5 years old for 620 (48 %) of their children.

The research team, Heller says, has already begun experiments to further explore the implications of these results, which include looking at differences in this pathway between cells taken from allergic and healthy individuals, and testing the efficacy of an inhalable drug that mimics the function of GRB1 and p70S6K to shut off the development of M2 macrophages in the lungs of mice.

They also found that vitamin D did not improve lung function or day - to - day asthma symptoms, and that it did not increase the risk of side effects at the doses that were tested.

Lung function was measured at the ages of 7, 13, 18, 45, 50 and 53 years old, and participants» exposure to various risk factors was also recorded.

Women who work as cleaners or regularly use cleaning sprays or other cleaning products at home appear to experience a greater decline in lung function over time than women who do not clean, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

«It has long been thought that ECAC did not contribute to poor lung function or respiratory symptoms,» said Surya Bhatt, M.D., assistant professor in the Division of Pulmonary, Allergy and Critical Care Medicine at UAB and lead author of the study.

The multisite team, led by researchers from the University of Alabama at Birmingham, suggests that ECAC, as measured by computed tomography scanning, is associated with poor lung function and respiratory symptoms.

Because of the beneficial effect of corticosteroids on lung function, especially in infants who are ventilator dependent, corticosteroids are, at times, administered to very low birth weight neonates to treat established or evolving lung disease.

In the aftermath of 9/11, New York City fire department rescue and recovery workers exposed to the caustic dust at the site experienced high rates of lung injury and excessive loss of lung function.

«After 9/11, about one in eight firefighters who worked at the World Trade Center had accelerated loss of lung function over the next 15 years,» Dr. Weiden said.

The patient doesn't collapse climbing the stairs, short of breath, until his lungs are functioning at 10 percent capacity.

The study also looked at smokers without airway obstruction to determine whether acute respiratory events were associated with a decline in lung function.

«Very early on in this disease — at a time when outside a study like ours the majority of people would not have been diagnosed with COPD — patients appear to be losing lung function,» said lead author Mark T. Dransfield, MD, medical director of the University of Alabama at Birmingham Lung Cenlung function,» said lead author Mark T. Dransfield, MD, medical director of the University of Alabama at Birmingham Lung CenLung Center.

Exacerbations of chronic obstructive pulmonary disease (COPD) accelerate the loss of lung function especially among patients with mild disease, according to researchers at National Jewish Health and other institutions.

«This association is important for lung development in mouse embryos, and at least for one of these long non-coding RNAs, important for human lung function.»

So anything we can do to make the lungs work better and anything we can do to make the lungs function better in the short term is likely to have lifelong impacts on how well these babies can think, how well they can walk, how well they can talk, and so forth,» said Dr. Shepherd, also a faculty member at The Ohio State University College of Medicine.

«It would be desirable to repeat lung function more extensively later in life, and at more sites to identify those participants at highest risk of developing severe breathing disorders in adulthood,» Dr. Doyle said.

In «Neonatal Caffeine Treatment and Respiratory Function at 11 Years in Children,» Dr. Doyle and colleagues report on their study to determine if the lung benefits of caffeine in premature babies persist in mid-childhood.

Cook - Mills examined the CARDIA results for individuals» lung function tests at four intervals from baseline to 20 years and the type of tocopherol levels in their blood plasma at three intervals from baseline to 15 years.

Dr Sam Parnia, Assistant Professor of Critical Care Medicine and Director of Resuscitation Research at The State University of New York at Stony Brook, USA, and the study's lead author, explained: «Contrary to perception, death is not a specific moment but a potentially reversible process that occurs after any severe illness or accident causes the heart, lungs and brain to cease functioning.

However, this study indicates that not all at risk patients show accelerated lung function decline, which may explain why, so far, the effect of various treatments of lung function decline has been difficult to establish.

«This long - term chronic disease can be developed in different ways, so achieving normal growth in lung function in early adulthood is an important factor in terms of future risk,» says Peter Lange, Consultant in Respiratory Medicine at Hvidovre Hospital and professor at the Department of Public Health, University of Copenhagen.

Lungs perform at least three functions: they bring in oxygen and clear out carbon dioxide, they regulate the body's balance of acidic and basic compounds required for proper organ functioning, and they filter out the soup of foreign particles we constantly inhale.

The researchers found that the addition of vitamin D3 to ciclesonide did not significantly reduce the rate of first treatment failure (a composite outcome of decline in lung function and increases in use of beta - agonists, systemic steroids, and health care utilization) compared with placebo; 28 percent and 29 percent of participants in each group, respectively, experienced at least 1 treatment failure during 28 weeks.

Now an international team of researchers led by the lung researcher Marianne Geiser from the Institute of Anatomy at the University of Bern and the aerosol researcher Josef Dommen from the Paul Scherrer Institute PSI has shown that secondary particles from gasoline combustion in Euro 5 engines directly damage lung tissue as well as weaken its defense functions.

At one end of the spectrum, thick mucus derailed the function of the body: It blocked the pancreas from delivering enzymes needed for food digestion and absorption, resulting in malnutrition, and also caused severe lung infections, often killing children by age 5.

They also measured HDL cholesterol, cardiorespiratory fitness, lung function and the length of the telomeres — protective caps at the end of chromosomes that have been found to shorten with age.

«The few studies that have been done use methods to interpret pulmonary function involving spirometry test criteria which the European and American lung research organisations ERS and ATS now consider outdated and unable to produce reliable results.

«The impact of chronic smoking on the lungs and the individual is substantially underestimated when using lung - function tests alone,» said James D. Crapo, professor of medicine at National Jewish Health and senior author of the study, which is being published June 22, in JAMA Internal Medicine.

But this study led by the scientists at the University of Leicester and University of Nottingham has identified many new genetic variants which are associated with enhanced or worsened lung function in both smokers and non-smokers.

Asthma status and lung function were determined at ages 5, 10 and 15 years.

Now, researchers at the University of Missouri School of Medicine have found that a commonly used pulmonary lung function test can provide early detection of asthma before a child shows any symptoms of breathing problems.

Respiratory tract infections in young children are linked to an increased risk of asthma and worse lung function in later life, according to new research to be presented at the European Respiratory Society International Congress today (Sunday).

«At the age of eight years, asthma is usually well established, as is lung function.

However, lower respiratory tract infections at almost all ages were associated with worse lung function as indicated by lower scores for FVC, FEV1 and FEF75.

Research presented today (5 September, 2016) at this year's European Respiratory Society (ERS) International Congress in London shows that reduced fetal size is linked to increased asthma risk and reduced lung function in children aged 5 to 15 years.

Further, tumor to lung volume ratio was substantially lower in mice without Notch1 function; this ratio was 6 % at 6 weeks, 17 % at 18 weeks, and 20 % at 24 weeks in normal mice, and 4 %, 11 %, and 9.5 %, respectively, in the Notch1 - knockdown mice.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.