Sentences with phrase «lung immunopathology»
The concern for an occurrence of lung immunopathology on challenge of mice vaccinated with an inactivated virus vaccine, as reported by Haagmans, et al. for ferrets and nonhuman primates, was seen by us after challenge of mice vaccinated with a SARS VLP vaccine [20].
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They found that IL - 27 levels in infected lungs follow, with some delay, the level of virus: they peak as viral levels are starting to decline and come down when immunopathology has resolved.
The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»
That lung disease exhibited the characteristics of a Th2 - type immunopathology with eosinophils in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2 - type immunopathologic reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally - occurring RSV [32]--[33].
The immunopathology in all experiments in the present study occurred in the absence of detectable virus in lungs of mice two days after challenge with infectious virus.