Sentences with phrase «lung injuries in»

These findings suggest that targeting NFAT activity might be a useful way to ameliorate lung injury in severe streptococcal infections.

By triggering a process called autophagy — in which cells literally engulf their own insides — researchers from Drexel University and Yale University were able to decrease lung injury in mice that were exposed to high concentrations of oxygen.

«By causing cells to cannibalize themselves, researchers prevent lung injury in mice.»

Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2 - event in vivo rat model.

The use of technetium - 99m hexamethylpropylene amine oxime lung scintigraphy in the detection of subclinical lung injury in patients with noninsulin - dependent diabetes mellitus.

Calcitonin gene - related peptide (CGRP) has been shown to improve survival of lung epithelial cells and reduce hyperoxic lung injury in rats.

Not exact matches

One flavonoid in lemongrass called luteolin has such strong anti-inflammatory abilities that it may be able to treat some symptoms of multiple sclerosis, as well as lung infections or acute lung injury.

He suffered «multiple chest injuries, lung damage, a broken right leg, broken pelvis, broken right arm and concussion» in the hefty qualifying shunt.

You shouldn't ignore the persistent hiccups in your child, since this can be a symptom of brain damage; various diseases of the stomach, liver or lungs; injuries of the spinal cord and the chest.

They discovered that in the young, more immune cells called monocytes were recruited to the lungs, and that the gene expression profiles of these cells had more inflammatory features, causing greater inflammation and more severe lung injury.

Highly pathogenic (dangerous) influenza strains elicit a strong immune response which can lead to uncontrolled inflammation in the lung and potentially fatal lung injury.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

The discussion also covers the management of common long - term complications such as heterotopic ossification, in which solid masses of bone begin growing inappropriately within soft tissues near blast injury sites, and the formation of blood clots in the extremities and lungs, which occurs at a high rate in DCBI survivors.

Ischemic heart disease tops the list, followed, in order, by trachea, bronchus and lung cancers; stroke; chronic obstructive pulmonary disease; road injuries; suicide; and diabetes.

In the aftermath of 9/11, New York City fire department rescue and recovery workers exposed to the caustic dust at the site experienced high rates of lung injury and excessive loss of lung function.

In AE, widespread lung injury is superimposed on the pulmonary fibrosis, which frequently occurs before patients die.

While the autopsy showed low levels of carbon monoxide in the woman's blood, it also revealed extensive thermal injuries in her air passages and lungs.

Mark Gladwin, a researcher in pulmonary medicine at the National Heart, Lung, and Blood Institute (NHLBI) in Bethesda, Maryland, says that the nitrite levels in the Tibetans» blood are similar to those NHLBI researchers are using to treat heart and liver injuries caused when blood is restored to oxygen - deprived tissues in experimental animals.

But in IPF lungs, cells undergo ongoing injury, so CHI3L1 is chronically elevated and scar tissue accumulates.

Zhang, a member of Ohio State's Davis Heart and Lung Research Institute, is particularly interested in bioadhesives that could aid in wound healing after injury or surgeries.

Crouch and his colleagues found that those in the low PVR group had lower mortality (0 vs. 1.1 %) and fewer complications, including delirium (7.8 % vs. 14.9 %), pneumonia / tracheobronchitis (6.3 % vs. 15.5 %), and a statistically significant lower rate of reperfusion lung injury (7.8 % vs. 25.9 %), The low PVR group also experienced statistically significant recoveries, with less time spent on the ventilator (1.7 vs. 3.2 days), in the ICU (4 vs. 5.8 days) and in the hospital (13 vs. 16.3 days).

To find out whether increasing cell self - destruction in the lungs could actually decrease cell death — and ultimately prevent lung injury — Bhandari and his research team targeted a regulator protein called RPTOR, which when inhibited, is responsible for inducing autophagy.

If this type of therapy proves safe in humans, a syringe full of oxygen microbubbles could help avert brain damage and death for the victims of cardiac arrest, asthma attacks, strokes, and injuries to the lungs, airway, or face.

Further, in laboratory mice, the team found that by deleting this substance, they could produce the type of scarring found in pulmonary fibrosis after lung injury.

The worst chlorine gas accident in the country occurred in 2005, when 18 freight train cars derailed and released 120,000 pounds of chlorine gas in the mill town of Graniteville, S.C. Nine people were killed and at least 1,400 people were exposed, resulting in more than 550 people treated at hospitals, including some with serious lung injuries.

Studies show 40 - 60 ppm produces lung injury; 430 ppm usually causes death in 30 minutes, and 1,000 ppm is fatal within a few minutes.

Researchers at Johns Hopkins University checked in with survivors of a lifethreatening lung injury for two years after they were discharged from the ICU.

An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1.

Two studies published in the January issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists ® (ASA ®), shed new light on the prevalence of transfusion - related acute lung injury (TRALI) and transfusion - associated circulatory overload (TACO), the number one and two leading causes of blood transfusion - related deaths in the United States.

Original publication: Schiller, HB et al. (2015) Time - and compartment - resolved proteome profiling of the extracellular niche in lung injury and repair, Molecular Systems Biology, DOI:: 10.15252 / msb.20156123 Link to the publication

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

The primary outcome is in - hospital mortality, and secondary outcomes include the complications of BSI such as septic shock, acute kidney injury (AKI), acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), ischemic liver injury, and a collapsed dependent variable of «poor clinical outcome» that is defined as the presence of any of the above complications.

Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion - related acute lung injury.

Impact of bone marrow - derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice Mouchira M Mohi El - Din, Laila A Rashed, Mohi A Mahmoud Haridy, Atef Mohamed Khalil, Mohamed A Mohamed Albadry.

Conclusions: CGRP stimulates the expression of multiple molecules in the Wnt 7b / β - catenin pathway in AEC II under hyperoxia, which might be part of the mechanism by which CGRP protects the lung from hyperoxia - induced injury.

Takayama's team was able to confirm that the sounds were associated with injury to the cells — suggesting that the model was accurately approximating what happens in a diseased lung — and to show how a therapeutic surfactant, which lowers the tension between liquids and solids, could reduce those injuries.

Background: Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

The role of integrin [alpha] 8 [beta] 1 in fetal lung morphogenesis and injury.

Since we observed robust inhibition of NFκB in the presence of RIPK2 inhibitor 1 and a > 70 % recovery of animals from DSS - induced inflammation injury (Figs. 4 and 6B), we proceeded to explore the ability to resolve lung inflammation using the ovalbumin challenge model (Kumar et al., 2008).

Examples include a series of studies to document persistent microchimerism of donor cells in transfusion recipients, with particular focus on mechanisms and clinical relevance of donor stem cell microchimerism in transfused trauma patients, and the immunological mechanisms and prevention of transfusion - related acute lung injury (TRALI) and alloimmunization.

In the elderly, lung injury from inhaled particles or from infections might lead to undue scarring processes, some of which in turn lead to lung fibrosis and respiratory insufficiencIn the elderly, lung injury from inhaled particles or from infections might lead to undue scarring processes, some of which in turn lead to lung fibrosis and respiratory insufficiencin turn lead to lung fibrosis and respiratory insufficiency.

Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II Alveolar Epithelial Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.

Time and compartment ‐ resolved proteome profiling of the extracellular niche in lung injury and repair

The HARP study showed that 80 mg of simvastatin administered acutely to patients with acute lung injury showed significant improvements in organ failure scores, suggesting that statins modulate the systemic inflammation after only a short duration of treatment [17].

We often treat people who have fallen off of high ladders, which results in serious and extensive injuries (head trauma, collapsed lungs).

But her lower limbs were not the extent of her injuries, which also included a broken sternum, ribs, and pelvis, in addition to bruising to her heart and lungs, Global News reported.

Further research showed that a bacterial toxin called endotoxin was circulating in the bloodstream following this meal, causing inflammation and injury in the heart and lungs.

Rhamnazin has also shown protective properties against inflammation in acute lung injury, inhibiting the metabolism of cytokines, which are proteins secreted by the immune system in order to affect cellular functions.

A recent study in the New England Journal of Medicine showed that coffee drinkers had a lower risk of dying from heart disease, lung disease, pneumonia, stroke, diabetes, infections — and even injuries and accidents!