Sentences with phrase «lung metastasis of»

Immunological Invisibility Cloak Among them is Joel Linden, Ph.D., who recently reported that jamming signals transmitted by membrane proteins called adenosine receptors, which are expressed on T cells and on specialized cell - killing cells called NK cells, made both cell types more effective in halting lung metastasis of melanoma cells.

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

E2F1 is known to contribute to the development of cancer by promoting cancer cell proliferation; however, this is the first time that E2F1 has been shown to contribute to metastasis of lung cancer.

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

In the first series of tests, researchers found that luteolin inhibited the metastasis of triple - negative cancer in the lungs of affected mice.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

Breast cancer has a high rate of metastasis to bone, lung, liver, lymph nodes, and the brain.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

«New gene discovered that stops spread of deadly cancer: Scientists identify gene that fights metastasis of a common lung cancer.»

Rejection of lung melanoma metastasis in mice lacking the gene for Cbl - b (down left) or carrying a mutation in this gene (down right), as compared to Cbl - b sufficient mice (upper panels).

«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.

Their initial experiments found increased bone activity in two mouse models of a common form of lung cancer and in 70 lung cancer patients, even in absence of bone metastasis.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

«In this study, we found that enhanced neuropilin - 1 (NRP - 1) and NEDD9 levels in endometrial and lung cancer positively correlated with metastasis, while liver kinase B1 (LKB1) inhibited the migration of cancer cells.»

The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Center.

Cancer biologist Joan Massagué of the Memorial Sloan - Kettering Cancer Center in New York City uncovered the new clues by studying breast cancer metastasis, in which malignant cells tend to spread to the bones and lungs.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

Shah and his team are currently developing similar animal models of brain metastasis from lung cancers and from melanoma.

The second experiment is to isolate various cell types from lungs harboring metastasis to confirm the cellular source of periostin in response to metastatic growth.

Of note, most patients that develop metastasis to the liver do not do so to the lung, thanks to maintenance — among other factors — of appropriate p38 MAPKinase levelOf note, most patients that develop metastasis to the liver do not do so to the lung, thanks to maintenance — among other factors — of appropriate p38 MAPKinase levelof appropriate p38 MAPKinase levels.

Of the colon cancer patients that develop metastases, 40 % present metastasis first to the liver and later to the lung, always in this clinical order of appearancOf the colon cancer patients that develop metastases, 40 % present metastasis first to the liver and later to the lung, always in this clinical order of appearancof appearance.

She studies the process of cancer initiation and progression along with cancer stem cells, the evolution of drug resistance and the dynamics of metastasis formation focusing on lung, brain, breast and pancreatic cancers.

AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases.

What: The Second Edition of the IASLC Staging Manual in Thoracic Oncology reports on the latest revisions of the tumor, node and metastasis (TNM) classifications of thoracic malignancies, namely, lung cancer, malignant pleural mesothelioma, carcinoma of the esophagus and of the esophago - gastric junction and thymic epithelial tumors.

Oral delivery of PND - 1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

[39] These results underscore the importance of monitoring long - term treatment of CNS metastasis in this subtype of lung cancer, and the importance of focusing on non — WBRT - based treatments to achieve a meaningful response.

In the orthotopic breast cancer model around 12 % of tail injected iPSC - EPCs homed to the mammary pad region, while in the breast cancer lung metastasis model iPSC - EPCs were distributed predominantly to the lung region.

Oral administration of mebendazole in mice elicited a strong antitumor effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with paclitaxel - treated mice [9,20].

Tracing of lung metastasis following surgical removal of the primary tumour identified more detectable metastases in Tie2PEKO mice compared to WT mice (Supplementary Fig. 12c, d).

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Her group has developed pre-clinical models of metastatic disease that are used to identify genes, both in the tumour cells and in the tumour micro-environment that regulate the process of metastasis to specific organs such as bone, liver, lung and brain.

The sum of metastatic tumor volume was first calculated from four lobes of lungs per animal (see Materials and methods), and the lung metastasis per group is presented as tumor volume (cubic millimeters).

A peptide that inhibits function of Myristoylated Alanine - Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis

The MDA - MB - 231 — derived 1833 cell line, which is characterized by enhanced bone - specific metastasis compared to the parental cell line or cell lines with increased tropism to lung and brain, showed increased abundance of ABL1 and ABL2 (fig.

Depletion of ABL kinases does not inhibit metastasis of 4175 breast cancer cells, which show tropism to the lung.

Whitehead Institute researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast, colon, and lung cancers.

Cancer that comes from another part of the body to the lungs is called pulmonary metastasis.

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

The experimental metastasis assay we detail here includes tail - vein injection of cancer cells into the mouse and determination of the resulting secondary organ colonization, primarily in the lung, 10 d post dosing.

Lung cancer metastasis could be stopped by targeting a couple of proteins in the Golgi apparatus, reported a study.

To do so, they injected melanoma cells into the bloodstream of normal or E2 mutant mice and monitored lung metastasis.

Now, a study published by the University of Texas MD Anderson Cancer Center is confirming that too much sugar can lead to breast cancer and metastasis to the lungs.

If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue or other parts of the body.

The limitations of the chemo beads Although cisplatin beads are often effective at preventing or slowing the cancer from coming back, they do not prevent spreading (metastasis), e.g. to the lungs.

However, less than 5 % of these animals will actually have visible radiographic metastasis to the lungs at the time of presentation.

The goal was to see if we can slow or stop the formation of lung metastasis (spread of tumor to your dog's lungs which occurs in over 90 % of cases).

These tumors have an extremely high rate of metastasis, often traveling to the lungs where they quickly become deadly.

Ideally, the lung metastasis, or the spread of the tumor to the dog's lungs (which occurs in more than 90 percent of osteosarcoma cases), will be slowed or stopped entirely by these NK cells.

Occasionally, metastasis can occur at distant sites (lungs, liver) without evidence of spread to the regional lymph nodes (termed «skip metastasis).