Sentences with phrase «lung stem cell»

In the long run, the scientists hope their lung stem cell therapy will also help patients with other lung fibrosis conditions of which there are dozens, including COPD, cystic fibrosis, and fibro - cavernous pulmonary tuberculosis.

In 2014, the National Institutes of Health helped to fund the first of its kind lung stem cell repository, which provides researchers open (free) access to the different types of induced pluripotent lung cells to use in their laboratories.

PNAS June 2009), and he is currently determining the key signalling pathways that mediate lung stem cell growth, quiescence and differentiation.

She has generated multiple genetically altered mouse strains to facilitate lung stem cell analysis in vivo.

Similar tests on neural and lung stem cells are underway.

The most common form of lung cancer may begin in a group of newly isolated lung stem cells, according to researchers from the Howard Hughes Medical Institute.

«This is the first time anyone has generated potentially therapeutic lung stem cells from minimally invasive biopsy specimens,» said co-senior author of both papers Jason Lobo, MD, an assistant professor of medicine at UNC and medical director of lung transplant and interstitial lung disease.Co - senior author Ke Cheng, PhD, an associate professor in NCSU's Department of Molecular Biomedical Sciences and the UNC / NCSU Joint Department of Biomedical Engineering, said, «We think the properties of these cells make them potentially therapeutic for a wide range of lung fibrosis diseases.»

Through a joint UNC School of Medicine - NC State research project shows how to harvest lung stem cells non-invasively and then multiply healthy cells — a potentially powerful therapy against inflammatory lung conditions.

Through a joint UNC School of Medicine - NC State research project shows how to harvest lung stem cells non-invasively and then multiply healthy cells — a potential powerful therapy against inflammatory lung conditions.

Not exact matches

Panoskaltsis - Mortari's team has been working on rebuilding lungs and other parts of the respiratory system using human stem cells.

MIMICKING the environment experienced by cells in the windpipe is enough to transform stem cells into a range of different lung cells.

Many scientists believe that targeting a type of cell called a cancer stem cell may be necessary to completely cure lung cancer.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

They reported that YAP1 is found at high levels in lung cancer stem cells and binds to a protein called OCT4.

Further preclinical work will be needed to use the herpes - loaded stem cells for breast, lung and skin cancer tumors that metastasize to the brain.

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

«Potential of stem cell therapy to repair lung damage.»

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

Those at highest risk are people whose immune systems are suppressed, such as those undergoing stem cell and lung and other organ transplants.

«Physical forces are certainly a factor in getting the lung lining to be fully functional,» says Anne Bishop at Imperial College London, who has made alveolar cells from mouse stem cells using growth factors alone.

Previously, stem cells have been made to differentiate into lung cells using a cocktail of different growth factors, but Haute says using physical forces might be simpler.

«Scientists turn human induced pluripotent stem cells into lung cells: «Bronchospheres» may pave way for personalized cystic fibrosis treatments.»

Once the stem cells are created, Niklason relies on different chemical markers left behind in the decellularized lungs to guide the stem cells to their correct locations.

Now, scientists at Boston University's Center for Regenerative Medicine (CReM) have announced two major findings that further our understanding of this process: the ability to grow and purify the earliest lung progenitors that emerge from human stem cells, and the ability to differentiate these cells into tiny «bronchospheres» that model cystic fibrosis.

It reproduces the lung's natural environment in the body, from the physical forces to the chemical soup — all to help manipulate stem cells to mature into specific tissue.

But with humans, she is using iPS cells and has been working to develop the correct protocols to induce her stem cells to differentiate into different kinds of lung tissue.

Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells.

«Novel method for generating airway cells from stem cells: May lead to possible cures for lung diseases including cystic fibrosis.»

Researchers hope that the results, published separately in the Journal of Clinical Investigation and Cell Stem Cell, will lead to new, «personalized medicine» approaches to treating lung disease.

«If you look at a set of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

«These aren't classic stem cells that we see regenerating the lung.

• A Yale research team led by Diane Krause turned a single stem cell from the bone marrow of an adult mouse into lung, liver, intestinal, and skin cells for other mice.

In practice, however, lung cells — especially from older, ill patients — won't grow well enough in culture, but will have to be produced from stem cells or induced pluripotent stem (iPS) cells, she says.

«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.

«Stem cell therapy may help recondition lungs previously rejected for transplant.»

«If I had your stem cells and created a heart, liver, lung and an ovary, I could test 10 different drugs at 10 different doses on you and say, «Here's the drug that will help your Alzheimer's or Parkinson's or diabetes,»» Woodruff said.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

«The introduction of mitochondria into damaged cells has beneficial effects on the health of cells and, in the long term, we believe that mesenchymal stem cells could even be engineered to create more effective therapies for lung disease in humans.»

A research team has identified a protein that increases the transfer of mitochondria from mesenchymal stem cells to lung cells.

Researchers need to identify cells — possibly adult stem cells from the patient — that can reconstruct lung tissue without provoking attack by the immune system, the problem that plagues current transplant recipients.

Using patient - derived stem cells known as induced pluripotent stem cells (iPSC) to study the genetic lung / liver disease called alpha - 1 antitrypsin (AAT) deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease.

«The exciting aspect is that we have learned how to isolate these stem cells from diseased lungs.

The trial, published in Circulation Research, was designed to test the feasibility and side effects of a genetically - enhanced stem cell therapy to repair and regenerate lung blood vessels in PAH.

The treatment is promising enough that research teams around the world are developing similar stem cell therapies that can target and eradicate cancers of the prostate, lung, breast, skin and other tissues.

«Study finds cause of pulmonary fibrosis in failure of stem cells that repair lungs.»

The stem cells that proliferate the most in response to damage caused by cigarette smoke repair their DNA using a process prone to errors, setting the stage for lung cancer, according to a study publishing January 26, 2017 in the open - access journal PLOS Biology by Marie - Liesse Asselin - Labat and her team of the Walter and Eliza hall Institute of Medical Research, Australia.

«Stem cells to treat lung disease in preterm infants.»

In a study appearing in Science Translational Medicine, the researchers report they have effectively and safely employed this stem cell - targeting system in mice to treat metastatic breast cancer that had spread to the lung.