Through a joint UNC School of Medicine - NC State research project shows how to
harvest lung stem cells non-invasively and then multiply healthy cells — a potentially powerful therapy against inflammatory lung conditions.
Through a joint UNC School of Medicine - NC State research project shows how to harvest
lung stem cells non-invasively and then multiply healthy cells — a potential powerful therapy against inflammatory lung conditions.
The disease, which has no known cure, appears to result from the failure of
special lung stem cells that help airways recover from injury, the investigators reported in the journal Nature Medicine.
The most common form of lung cancer may begin in a group of newly
isolated lung stem cells, according to researchers from the Howard Hughes Medical Institute.
In 2014, the National Institutes of Health helped to fund the first of its
kind lung stem cell repository, which provides researchers open (free) access to the different types of induced pluripotent lung cells to use in their laboratories.
Smoking is a strong risk factor for squamous cell carcinoma, the second most common form of lung cancer, but the relative contributions to carcinogenesis of two types
of lung stem cells (basal cells and alveolar progenitor cells)-- and the molecular reasons for accumulation of the DNA damage that leads to cancer — have not been clear.
Similar tests on neural and
lung stem cells are underway.
In the long run, the scientists hope
their lung stem cell therapy will also help patients with other lung fibrosis conditions of which there are dozens, including COPD, cystic fibrosis, and fibro - cavernous pulmonary tuberculosis.