Sentences with phrase «lung tissue as»

Now an international team of researchers led by the lung researcher Marianne Geiser from the Institute of Anatomy at the University of Bern and the aerosol researcher Josef Dommen from the Paul Scherrer Institute PSI has shown that secondary particles from gasoline combustion in Euro 5 engines directly damage lung tissue as well as weaken its defense functions.

So far, scientists have used the printers to produce heart and lung tissue as well as cartilage and bone.

PCR results were positive from post-necropsy liver and lung tissues as well as from sera, conjunctival swabs, oral swabs, and nasal swabs collected at time of quarantine in 8 different affected monkeys, but were negative from a throat swab from an asymptomatic animal whose other 5 cage mates had become sick.

Not exact matches

Avoid talc - based powders, as they contain tiny particles that irritate the skin and the delicate tissues of the lungs.

As your baby grows, she will grow new, healthy lung tissue and the symptoms will get better.

It not only refers to muscle tissue, but also includes fat or non-muscle organs such as lungs, liver, and kidney.

And even if that hurdle could be crossed, a viable dinosaur might not last long in 2006: «As far as we know, the way the lung tissue functioned, the way the hemoglobin functioned, was designed for an atmosphere that's very different than today's.&raquAs far as we know, the way the lung tissue functioned, the way the hemoglobin functioned, was designed for an atmosphere that's very different than today's.&raquas we know, the way the lung tissue functioned, the way the hemoglobin functioned, was designed for an atmosphere that's very different than today's.»

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended timeAs it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended timeas those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

The discussion also covers the management of common long - term complications such as heterotopic ossification, in which solid masses of bone begin growing inappropriately within soft tissues near blast injury sites, and the formation of blood clots in the extremities and lungs, which occurs at a high rate in DCBI survivors.

The main cause is assumed to be a reaction of lung tissue to chronic exposure to toxic gases or particles such as from cigarette smoke.

While researching Del - 1 in other tissues, such as gums and lungs, Hajishengallis and Chavakis found that Del - 1 was also highly expressed in the brain.

Pigs that are notably distressed are not illegible to be slaughtered and as they go through the slaughter process there is veterinary inspection that looks issues and with the removal of lungs and those tissues, if there is any evidence of pneumonia or abscesses or that sort of thing, those pigs do not get into the feed supply.

But, he notes, «with all infections, part of the concern is that the inflammatory response can become too exuberant, which leads to tissue damage, as in septic shock,» and lung failure.

«So we had a setup so that we could perfuse the lung tissues and allow them to breathe as well, because breathing is important for lung development.

The experiments, including studies conducted in a bioengineered 3 - D model of lung tissue seeded with relevant cells, showed that CHI3L1 regulates a pathway that recruits cells such as macrophages and fibroblasts that produce the scarring, or fibrosis.

The researchers analyzed gene activity and degradation in 36 different kinds of human tissue, such as the brain, skin and lungs.

This shows promise for breast cancer patients as diagnosing and treating the breast cancer at early stages means there is a greater chance of preventing cancer cells spreading to other tissues, such as the lungs, brain and bone.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

Within the ribcage, there are patches of soft tissue that contain tubular structures in a branching pattern, which the team interprets as preserved lung tissue.

These lymphocytes, which reside in tissues such as the lungs, gut and reproductive tract, «can be stimulated very quickly,» Newcomb says.

«Running, or any kind high - intensity exercise, puts a strain on the heart muscle, as it does on lung tissue, and leg and arm muscles,» said Neel Chokshi, MD, an assistant professor of Clinical Cardiovascular Medicine, and medical director of the Penn Sports Cardiology and Fitness Program.

Transplant recipients who receive a kidney, heart, or lung often develop an immune response to the foreign tissue in the form of antibodies referred as donor - specific HLA antibodies.

For transmission electron microscopy, tissue fragments (2 × 2 mm) were excised from paraffin blocks of lung, deparaffinized, and processed as previously described [48].

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

• The key component of this research is dendritic cells, which serve as the gate - keepers of the immune system and are present in tissues in contact with the external environment, such as the skin and the inner lining of the nose, lungs, stomach and intestines.

Researchers at the University of Warwick have recovered tuberculosis (TB) genomes from the lung tissue of a 215 - year old mummy using a technique known as metagenomics.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could aLung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could alung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue culture model for Pseudomonas aeruginosa pathogenesis.

Resident macrophages from the same lineage, such as liver Kupffer cells, brain microglia, epidermal Langerhans cells, lung alveolar macrophages..., display tissue - specific phenotypes, perform tissue - specific functions and have distinct gene expression profiles.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

The Division of Pulmonary Medicine deals with the breath of life in all its aspects: control of breathing; sleep disorders; obstruction to airflow in the common diseases of upper and lower airways such as croup, bronchiolitis, asthma, cystic fibrosis, and bronchopulmonary dysplasia; restriction to lung function from disorders affecting the chest wall, the musculature, the nervous system, or lung tissue itself; congenital anomalies; accidents such as inhalation of foreign bodies, hydrocarbons, or toxic gases; secondary effects of non-pulmonary system disorders such as gastrointestinal reflux, myopathy, or cardiac dysfunction; disease of the upper respiratory tract including rhinitis and sinusitis; and so on.

Therefore the concept of administering treatment directly to the target tissue has been pursued in lung cancer with many forms such as; intratumoral6, 7, aerosol8 - 10 and intracavitary11.

In addition, the organs and tissues that possess high levels of SDF - 1, such as liver, lung, bone marrow, and lymph nodes, attract the migration of CXCR4 - expressing cancer cells [22].

Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins - exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis.

One of the most serious classifications of this disease is known as diffuse scleroderma wherein the «sclerosis» (hardening of the tissue) occurs in the internal systems of the body, causing damage and widespread scarring to the skin as well as to various internal organs such as the lungs, kidneys, heart and gastrointestinal organs.

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

â $ œWe have solved a major obstacle of using anti-miRNA as a therapeutic by being able to do a targeted delivery to only inflamed endothelial cells while all other tissues examined, including liver, lung, kidney, blood cells, spleen, etc showed no detectable side - effects, â $ Jo says.

Myofibroblasts can proliferate elsewhere in the body as well — although they may arise from different cell types in different tissues — and fibrotic remodeling of the kidney, liver (cirrhosis of the liver) and lungs follows a similar progression, Genin says.

Professor Zhou explained: «We built a database of epigenetic markers, specifically methylation patterns, which are common across many types of cancer and also specific to cancers originating from specific tissue, such as the lung or liver.

ORs are also expressed in non-olfactory tissues, including the kidney, heart, lung, and testes [9], [10], where they have been shown to work as chemoreceptors in human sperm chemotaxis [11], [12].

Each of Emulate's proprietary Organ - Chips — such as the lung, liver, brain, intestine or kidney — contains tiny hollow channels lined with tens of thousands of living human cells and tissues, and is approximately the size of an AA battery.

The researchers suggest that a single expandable embryonic lung progenitor population with broader developmental competence may eventually be used as an alternative for region - restricted adult tissue stem cells in regenerative medicine.

Topics of interest include gene - environment interactions, genetic associations with asthma - associated phenotypes such as allergies and lung function, and the role of tissue - specific gene expression.

San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.

Organ - Chips — such as the lung, liver, brain or kidney — are micro-engineered environments lined with living human cells and tissues.

With the promise of inhaled delivery, PRS - 060 may provide a targeted approach by binding as tightly to IL4Ra as clinically validated antibodies as well as antagonising IL4Ra directly in the lung tissue.

mastocytosis — is when you have too many mast cells which help protect us from infections in particular tissues such as the skin, lungs and bowel

p53 expression is usually not detected in dividing tissues such as skin, kidney, lung, stomach, or breast [11,12].