Sentences with phrase «lung tissue by»

The lungworm injures the airways or lung tissue by inciting an inflammatory reaction.

Not exact matches

The air sacs of the lungs, called alveoli, will be developed by the end of this week and will begin to secrete a substance called surfactant that keeps the lung tissue from sticking together.

Gas, essential for life which is carried by the blood from the lungs to the tissues; concentrated oxygen may be given through an ambu bag, ventilator, hood, nasal CPAP or prongs.

By 40 weeks, a baby's lungs are matured, the kidney and other vital organs are doing their thing, the brain has grown enough soft tissue that will set it up for the rest of life, and the neurological instincts that tell the baby to suck and swallow are kicked into gear.

One person who donates organs (hearts, lungs, liver, kidneys, pancreas and intestines) can save up to eight lives, while a tissue or eye donor (corneas, bone, skin, heart valves, tendons, veins, etc.) can improve more tha 75 lives by restoring eyesight, helping fight infections in burn patients and preventing the loss of mobility and disability.

MAS can affect the baby in a number of ways, including chemical irritation to the lung tissue, airway obstruction by a meconium plug, infection, and the inactivation of surfactant by the meconium.

The arthritis is accompanied or preceded by fever for at least two - weeks that is daily («quotidian») for at least 3 of those days, with one or more of the following symptoms: red rash (evanescent erythematous rash), enlarged liver, spleen or lymph nodes, and inflammation of the tissue lining (serositis) of the lungs, heart, or stomach.

Emissions from e-cigarette aerosols and flavorings damage lung cells by creating harmful free radicals and inflammation in lung tissue, according to the UR study published in the journal PLOS ONE.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

Over time, the lung is changed by secretions from the M2 cells, which cause the lung tissue to remodel itself, contributing to irreversible obstruction and poor lung function.

One of the things that makes this a difficult task is the fact that the lungs are constantly moving through the respiratory cycle; the movements caused by the patient breathing in and out, and those of the bronchoscope itself, mean that the tissue is changing shape and location during the examination.

The researchers confirmed their observations by studying tissue from lung cancer tumors.

«It seems that TB tricks the immune system into damaging our own lung tissue, which therefore makes the person highly infectious through coughing and the TB then spreads by aerosol droplets to other individuals.

In contrast to most normal tissues, switching off autophagy by deleting ATG7 was dramatically destructive to established non-small-cell lung cancers.

Lupus is an autoimmune disorder characterized by periodic inflammation of joints, connective tissues and organs including heart, lungs, kidneys and brain.

But the other report, published by the Ministry of Defence in March, did acknowledge that troops could have inhaled DU dust in the Gulf and that this «could theoretically lead to damage to lung tissue and subsequently to a raised probability of lung cancer some years later».

Griffiths also notes that emphysema, a lung disease common in smokers, is marked by a loss of connective tissue and may be related to increased MMP - 1 levels.

Funded by the U.S. Army, tissue engineers have begun developing designs for replacement organs — kidneys, hearts, and lungs.

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

By injecting short nucleic acids into rats, researchers have blocked an enzyme linked to swelling and tissue damage in the lungs.

The team then tested tissue from three other lung transplant patients who had died from hyperammonemia, including the patient studied by Wylam and colleagues.

Previous research, including pioneering work at MD Anderson by this study's senior author Ignacio Wistuba, M.D., and others, has shown normal - appearing tissue close to lung premalignant and cancer lesions may have tumor - associated molecular abnormalities.

SLE is a genetically complex chronic relapsing autoimmune disease characterised by inflammation that may affect different tissues, including the skin, joint linings, lungs, kidneys and other organs.

Researchers need to identify cells — possibly adult stem cells from the patient — that can reconstruct lung tissue without provoking attack by the immune system, the problem that plagues current transplant recipients.

A newly NIH funded clinical trial (NCT02528942) by University of Colorado Cancer Center investigators and collaborators at Beaumont Health in Michigan and the University of Texas Medical Branch is evaluating a new method for pinpointing and sparing healthy lung tissue during lung cancer radiotherapy.

Now an international team of researchers led by the lung researcher Marianne Geiser from the Institute of Anatomy at the University of Bern and the aerosol researcher Josef Dommen from the Paul Scherrer Institute PSI has shown that secondary particles from gasoline combustion in Euro 5 engines directly damage lung tissue as well as weaken its defense functions.

The multicentre trial included 153 patients with surgically - treatable malignant pleural mesothelioma, who were first treated with three chemotherapy cycles of cisplatin and pemetrexed, followed by surgical removal of affected lung tissue, with the goal of complete removal of the cancerous areas of lung.

It is a progressive, fatal disease characterized by scarring deep in the lung tissue that leads to respiratory or heart failure, pneumonia, and pulmonary embolism.

But in earlier work Drs. Summer and Romero have shown that when lung tissue is injured — by things like viral infection, particulate inhalation, or other insults — lung cells eventually stop producing lipids in order to conserve energy for other cellular repairs.

These proteins are crucial for tissue healing by instructing various processes, including the activation of specific stem cell populations, ensuring that lung tissue can be restored to its original condition.

A team led by infectious diseases researcher Charles Chiu of the University of California, San Francisco, analyzed lung tissue samples from the dead monkeys and identified a never - before - seen adenovirus, which they named titi monkey adenovirus (TMAdV).

Harvard Stem Cell Institute scientists at Brigham and Women's Hospital have found the cellular origin of the tissue scarring caused by organ damage associated with diabetes, lung disease, high blood pressure, kidney disease, and other conditions.

For tissue samples, lung or liver tissue was homogenized in a 15 mL Eppendorf tube using a disposable microtube pestle (Eppendorf, San Diego, CA) and scalpel, and RNA extraction was then performed using TRIzol LS (Invitrogen, Carlsbad, CA), followed by isopropanol precipitation and two washes in 70 % ethanol.

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

To confirm the presence of virus in diseased tissues, we examined lung tissue from affected monkeys by transmission electron microscopy, revealing abundant icosahedral particles characteristic of adenovirus filling the alveoli (Fig. 1D - 4).

Lab studies, animal studies, and observations of evacuated patients treated in Europe and the USA have suggested that Ebola might cause lung damage by replicating itself in lung tissue.

2 — photomicrograph of H&E stained lung tissue showing a severe diffuse necrotizing bronchopneumonia characterized by the presence of hemorrhage and intranuclear inclusions (arrows).

In particular, ultrasound - guided nerve blocking avoids potentially serious complications related to inadvertent puncture of the tissue lining the lungs (pleura), according to the report by Dr. Peter Stefanovich and colleagues of Massachusetts General Hospital, Boston.

In the case of gene editing, Verma is creating induced pluripotent stem cells (iPSCs) from patients by taking, for example, skin cells of patients, coaxing them back into an early stem cell state, and then providing conditions to make those cells develop into more complex brain, lung, prostate and breast tissues.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

One new way that scientists study this process of cellular development — and a way in which they hope to grow replacement tissue for medical treatments in the future — is by recreating the essential features of human brains, eyes, lungs, and guts in a petri dish.

pneumonia A lung disease in which infection by a virus or bacterium causes inflammation and tissue damage.

Published March 27 in Scientific Reports, a new study co-led by an NYU School of Medicine pathologist reveals that layers of the body long thought to be dense, connective tissues - below the skin's surface, lining the digestive tract, lungs and urinary systems, and surrounding arteries, veins, and the fascia between muscles - are instead interconnected, fluid - filled compartments.

â $ œWe have solved a major obstacle of using anti-miRNA as a therapeutic by being able to do a targeted delivery to only inflamed endothelial cells while all other tissues examined, including liver, lung, kidney, blood cells, spleen, etc showed no detectable side - effects, â $ Jo says.

Work in the 1960s on the lungs of guinea pigs led to a greater understanding of the function of chemicals that are released by tissues when normal biological processes are disturbedANCHOR.

With the promise of inhaled delivery, PRS - 060 may provide a targeted approach by binding as tightly to IL4Ra as clinically validated antibodies as well as antagonising IL4Ra directly in the lung tissue.

Featuring lectures by speakers from the University of Minnesota, UNC, Duke, NCSU and Wake Forest University, the symposium is open to the entire scientific community and a broad spectrum of topics will be covered including the Brain Connectome project, the effect of music on brain function, novel MR and OCT imaging techniques for the lungs, and advanced ultrasound methodologies for tissue characterization.

The body adapts to intense training by adding new capillaries, developing stronger heart and lung tissue, adding more energy producing mitochondria and increasing the bodies» tolerance to high levels of lactic acid accumulation (5).