Sentences with phrase «lungs of mice with»

This experiment uses quantitative PCR to detect the expression level of POSTN in CD34 + / CD31 − pulmonary fibroblasts, CD31 + endothelial cells, and CD45 + immune cells isolated from lungs of mice with macrometastases, which is a replication of the experiment reported in Figure 2H.

Not exact matches

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs of neonatal mice at the time of first RSV exposure reduces the development of allergic - type lung inflammation and airway hyperresponsiveness («twitchy» airways) in mice when they are «re-challenged» with RSV as young adults.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

When the researchers examined mice with disrupted IL - 27 function, they found that they were more likely than normal mice likely to die when infected with the virus, and that they died as a consequence of rampant lung inflammation.

Brueckner's group looked for gene defects in two strains of mice with situs inversus, a mutation in which the heart, lungs, and other organs are inverted, like a mirror image.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

«This was associated with an unexpected accumulation of T - cells in the lungs of infected mice that lack STIM1.»

All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other cells involved in the tissue repair response in both human and mouse lungs.

In addition, low levels of PD1 in the lungs of influenza - virus - infected mice were associated with severe infection and highly pathogenic viruses, such as H5N1.

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Adult male mice also started off with fewer of the lymphoid cells in the lungs than adult females, the researchers found: Female mice had about 1 1/2 times as many of these immune cells as males.

In a race with other scientists, Scottish researchers have bred mice with an altered gene which displays all the key features of cystic fibrosis, such as lung disease and digestive problems.

Finally, the researchers showed in tests with mice that their nanoparticle iNOP - 7DS can be delivered effectively to the liver, spleen, and lung; and it suppressed the level of messenger RNA involved in the expression of the ApoB gene.

Mice injected with breast cancer cells making lots of a long strand of RNA called HOTAIR developed 10 times as many lung tumors as controls (left) did.

Mice infected with a resistant strain of tuberculosis that were treated with both SMARt - 420 and ethionamide also showed a significantly reduced bacterial load in their lungs three weeks after infection compared to controls, the authors report.

In multiple trials of mice with both active and chronic TB infections, researchers report that one version of the new drug — an analog known as 1599 — was as good as or better than current TB drugs at reducing levels of the bacteria in the lungs of mice.

Here, we show that in germ - free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen - free mice.

The first experiment is to measure metastatic lung cancer in MMTV - PyMT transgenic mice crossed with the POSTN Knock out mice, and controls, with focus on the role of periostin in metastatic progression.

When the researchers administered daily doses of BCX to mice before and after they injected the rodents with a nicotine - derived carcinogen, they found that the mice treated with BCX had fewer lung tumors than those that got no BCX.

Oral administration of mebendazole in mice elicited a strong antitumor effect in a subcutaneous model and reduced lesions in experimentally induced lung metastasis without any toxicity when compared with paclitaxel - treated mice [9,20].

The dual - drug therapy — with analogs already in use for other diseases — doubled the survival rate of mice with lung cancer and halted cancer in pancreatic cells.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

Representative photomicrographs of lung tissue from unvaccinated unchallenged mice (normal) and from Balb / c mice two days after challenge with SARS - CoV that had previously been given PBS only (no vaccine) or live virus.

On day 56, five mice from each group were sacrificed for assessing serum neutralizing antibody titers and lung histopathology; the remaining seven or eight mice in each group were challenged with 106TCID50 / 60 µl of SARS - CoV intranasally (IN).

The concern for an occurrence of lung immunopathology on challenge of mice vaccinated with an inactivated virus vaccine, as reported by Haagmans, et al. for ferrets and nonhuman primates, was seen by us after challenge of mice vaccinated with a SARS VLP vaccine [20].

Representative photomicrographs of lung tissue two days after challenge of Balb / c mice with SARS - CoV that had previously been given a SARS - CoV vaccine.

The immunopathology in all experiments in the present study occurred in the absence of detectable virus in lungs of mice two days after challenge with infectious virus.

«We developed a new method of initiating lung cancer in mice, which has properties associated with human lung cancer, and used this model to identify the role of this enzyme in cancer proliferation.

We found no change in the total number of ILCs (Lin - CD45.2 + Thy1.2 + CD127 +) in the spleens, lungs or livers of toxin treated mice compared to mice that were injected with vehicle control (Fig 6A and S6A Fig).

Frozen sections of lung and colon tissues from wild - type mice and Slc6a14 − / − mice were also used for immunofluorescence analysis of Slc6a14 protein expression with an antibody raised against a mouse peptide sequence [17].

This strain showed a highly virulent phenotype, with rapid multiplication during the early stage of infection in a murine model of TB with excessive lung inflammation, and infection with this strain resulted in more rapid death of mice than infection with the reference H37Rv strain.

In this study, human lung cancer cells with additional copies of the opioid receptor grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.

Furthermore, by combining this information with the characterization of mice genetically engineered to develop lung tumours, we attempt to elucidate the key genes driving lung cancer initiation, progression and response to therapy.

Exposure to linalool, a terpene found in flowers and spice plants, decreased inflammatory damage in the lungs of smoke - exposed mice.12 Linalool is found in lavender and basil, and in keeping with terpenes ability to defend against plant prey, is used by exterminators as an insecticide.

In 2014, researchers published a study revealing that daily inhalation of lavender oil for two weeks reduced lung mucus lowered overall airway resistance in mice with experimentally induced asthma.

1) that the rate of mutations increase in mice exposed to SHS and 2) that the spectra of mutations in the SHS exposed mice is the same as in non - smoker humans with lung cancer.