Not exact matches
To their surprise, they found that these Th17 - deficient
mice experienced far more aggressive cancer growth
than normal mice — with the cancer completely smothering the
lungs within 16 days.
When the researchers examined
mice with disrupted IL - 27 function, they found that they were more likely
than normal mice likely to die when infected with the virus, and that they died as a consequence of rampant
lung inflammation.
Expression of CXCL16 was higher in the colon and
lung tissue of GF
mice than in
normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.
Female
mice and male
mice that had been treated with estrogen were able to clear the bacteria from their
lungs more rapidly
than normal male
mice.
Remarkably, outcomes following loss of the switch mirrored what the group had previously observed when they physically removed the gene itself: the
lungs of mutant
mice contained many more melanoma cells
than did
lungs of
normal mice.