In the case
of luteolin supplements for autism / spectrum, «You're giving prepubescent kids a supplement that affects the endocrine system and that's dangerous,» Nordeen says.
The
flavonoid luteolin worsens chemical - induced colitis in NF - kappaB (EGFP) transgenic mice through blockade of NF - kappaB - dependent protective molecules.
It also contains a flavonoid
called luteolin, which acts as an antioxidant and has extreme anti-inflammatory properties.
«Mice exposed to human triple - negative breast cancer cells experienced significantly reduced metastastic growth in their lungs after being treated
with luteolin,» Hyder said.
Hyder further
tested luteolin and its effects on subduing the migration of triple - negative breast cancer cells throughout the body.
In the first series of tests, researchers found that
luteolin inhibited the metastasis of triple - negative cancer in the lungs of affected mice.
Nordeen and colleagues show that
luteolin blocks some of the endocrine effects of the hormone progesterone.
We contend that these studies support further investigation of
luteolin as an anti-metastatic agent that could be used to combat triple - negative breast cancer and its metastasis.»
«In almost every case, the mice also saw no weight loss, which
means luteolin has no toxic effects; this plant compound is both safe and effective.»
Hyder and his research team have focused
on luteolin, a naturally occurring, non-toxic plant compound that has been proven effective against several types of cancer.
First, it acted like estrogen to directly stimulate cancer cell growth and second, by again blocking progesterone's action,
luteolin disabled the brake that progesterone puts on estrogen - dependent endometrial cancer growth.
Luteolin decreased activation of the cell signaling pathways Akt, PI3K, and CDC25c and ERK1 / 2 that are dependent on IGF - I.
The science - backed estrogen
blocker Luteolin, Asian Red Ginseng, Mucuna Pruriens, Nettle Root.
The flavonoids in parsley —
especially luteolin — have been shown to function as antioxidants that combine with highly reactive oxygen - containing molecules (called oxygen radicals) and help prevent oxygen - based damage to cells.
«When we provided the old
mice luteolin in the diet, it reduced inflammation in the brain and, at the same time, restored working memory to what was seen in young cohorts,» study researcher Rodney Johnson, a professor at the university, said in a statement.
The flavonoids present in horsetail include glycosides of the flavone apigenin and the
flavone luteolin, as well as glycosides of the flavonol quercetin and the flavonol kaempferol.
Olive leaf also contains some other medicinal compounds: hydroxytyrosol, vabascoside,
luteolin -7-glucoside, and apigenin -7-glucoside.
But recent studies also show that the phytonutrient content of EVOO — including its phenolic compounds like hydroxytyrosol and its flavonoids
like luteolin — are not stable to heat and degrade relatively quickly.
One flavonoid
called luteolin — which is found in foods like celery, parsley and thyme — has been shown to inhibit cell signaling in colon cancer.
For example, when heated in a container over a flame for only 5 minutes at a temperature of 461 °F / 188 °C, one study has shown 50 % loss of hydroxytyrosol and 69 % loss
of luteolin.
Parsley is very rich in the flavone apigenin and also
contains luteolin, kaempferol, quercetin and myricetin.
The research team tested the cells in dishes that were treated
with luteolin and found that migration was inhibited by the plant compound.
Using human triple - negative breast cancer cells grown in mice, the research team
tested luteolin to determine if it could suppress metastasis.
In the present work, Nordeen showed that
luteolin blocked this increase — a beneficial effect.
His study explored the effects of the
flavonoids luteolin and quercetin on cell models of breast and endometrial cancer.
•
luteolinidin — black sorghum, sumac sorghum, purple corn • cyanidin -3-O-β-glucoside — black rice, purple corn, scarlet corn, blue corn • luteolin: oregano, celery seed, juniper berries, thyme, radicchio • apigenin: parsley, celery seed, kumquats, celery hearts, oregano • quercetin: capers, radishes, dill weed, coriander / cilantro, oregano, onions
Recent studies show that phenols and polyphenols in EVOO — for example, hydroxytyrosol or
luteolin — are not stable to heat and degrade relatively quickly.
One flavonoid in lemongrass called
luteolin has such strong anti-inflammatory abilities that it may be able to treat some symptoms of multiple sclerosis, as well as lung infections or acute lung injury.
Now, University of Missouri researchers have found that
luteolin, a natural compound found in herbs such as thyme and parsley, and vegetables such as celery and broccoli, could reduce the risk of developing metastasis originating from triple - negative breast cancer in women.
But then in an endometrial cancer cell model,
luteolin had two deleterious effects.
In over-the-counter supplement form, the first compound,
luteolin, is commonly recommended for the treatment of pediatric autism spectrum disorders.
Rooibos has also been identified as a source of the flavonoids
luteolin and Quercetin, containing about 1.5 mg per cup.
Natural compounds such as apigenin, baicalein, catechins, curcumin,
luteolin, resveratrol and rutin have all been suggested to dampen brain inflammation levels.
Researchers revealed that
luteolin could prevent the colon cancer cell secretion of IGF - II and in just 2 hours reduced the level of receptor (IGF - IR) precursor protein.
Luteolin restricted the IGF - I growth stimulatory effect and the researchers discovered that luteolin affected IGF - I activated cell signaling pathways in cancer.
Luteolin is a flavonoid which is found in abundance in celery and in lesser amounts in other vegetables and fruits.
Research now reveals that
luteolin has the ability to restrict the activity of the IGF and PI3K cell signaling pathways necessary for the development of cancer found in cancer cells of the colon.
It's rich in two phytonutrients — orientin and
luteolin — that activate genes for new bone development.
These phytonutrients include: caffeic acid, caffeoylquinic acid, cinnamic acid, coumaric acid, ferulic acid, apigenin,
luteolin, quercetin, kaempferol, lunularin, beta - sitosterol and furanocoumarins.
Included in the list of cabbage flavonoids are the following anti-inflammatory compounds: artemetin, betanidin, butein, equol, hydroxyflavone, kaempferol,
luteolin, malvidin, naringenin, pelargonodin, purpurogalin, quercitol, and tetrahydrochalcone.
These are chlorogenic acid,
luteolin, and isochlorogenic acid, and they are present in the stem of the plant.
They perfume the skin naturally, as they contain aromatic compounds like diosmetin, apigenin, rosmarini acid,
luteolin, etc..
Cantaloupe contains a wide variety of antioxidant and anti-inflammatory phytonutrients, including the carotenoids alpha - carotene, beta - carotene, lutein, beta - cryptoxanthin and zeaxanthin; the flavonoid
luteolin; the organic acids ferulic and caffeic acid; and two cucurbitacins — cucurbitacin B and cucurbitacin E. Cantaloupe is an excellent source of vitamin A (in the form of carotenoids) and vitamin C.
Other study showed that palm date fruits constitutes thirteen flavonoid glycosides of
luteolin, quercetin, and apigenin at different stages of maturity.
It's flavonoids (
luteolin) function as antioxidants which help protect cells from oxidizing and damage