Sentences with phrase «lycopaoctaene synthase»

Through a lot of boring sciencey steps, our body produces something called nitric oxide synthase (NOS) which may cause blood vessels to expand, reducing blood pressure.

In animal studies, activation of nuclear factor - kappa B (NF - kB); activation of inducible nitric oxide synthase (iNOS), and cyclooxygenase - 2 (COX - 2); and formation of malondialdehyde (MDA) have all be shown to get reduced following consumption of either sweet potato or its color - containing extracts.

ZmPSY1 — phytoene synthase from another food crop, maize, which catalyzes the condensations of two molecules of geranylgeranyl diphosphate to form 11 - cis - phytoene, the first committed step in the carotenoid biosynthetic pathway;

She discovered that the enzyme made by the phytoene synthase was the «bottleneck» in production.

To produce Golden Rice, 2 enzymes are introduced into the endosperm [phytoene synthase (psy) and phytoene desaturase (crtl)-RSB- via an endosperm - specific glutelin (Gtl) promoter (15), to establish a β - carotene biosynthetic pathway in the rice grains.

One, called phytoene synthase, had been taken from daffodils.

The genetically modified organism (GMO) is wheat Triticum aestivum, which has been transformed with one or both of the following synthetic genes: (E)- β - farnesene synthase and farnesyl diphosphate synthase.

The researchers then modeled a new system with the same process: the mitochondrial enzyme ATP synthase, which also exhibits a distinct conformational change that is dictated by the application of force to the enzyme structure, which is propagated via tensegrity.

Changing the concentration of the enzyme's substrate molecule in the model produced an outcome that described how ATP synthase interacts with its microenvironment.

The sequence of the strands is designed to knock down the GM3 synthase gene.

The treatment did nothing; GM3 synthase was not reduced, and the ulcer healing was as slow as in the control mice treated just with the moisturizer or with a scrambled form of the SNA.

The researchers say that blocking IL - 1 halted a cascade of inflammatory responses that would otherwise lead to the activation of neuronal nitric oxide synthase in the fetal brain, an enzyme implicated in neurotoxicity.

In earlier work, Paller's lab had discovered that depleting an enzyme called GM3 synthase made cells particularly sensitive to growth factors and led to normal wound healing despite diabetic conditions.

In wild - type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ - mediated increase in inducible nitric oxide synthase expression.

Through a meticulous series of experiments, Tang homed in on one nutrient, a fatty acid called myristic acid, whose abundance, it turns out, worms can «monitor» using an enzyme called acyl - CoA synthase 4 (ACS - 4).

«Most interestingly, we found a similar dynamic, or circadian, looping when we studied a gene called Glycogen synthase 2,» says Felix Naef.

They used cryo - EM analysis to decipher the engineered ATP synthase, which was synthesized in yeast and reconstituted into nanodiscs to allow for structural analysis.

A team of scientists headed by Rosalind Franklin University Professor David M. Mueller, PhD, has solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, the major energy source of cells.

Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.

The study, published by the journal Science via First Release on April 12, paves the way for determining the structures of other functional states of the ATP synthase, which has been the subject of structural studies for decades in labs across the globe.

Structure of the monomeric yeast ATP synthase, shown as a surface representation, as determined by cryo - electron microscopy.

Later, it was learned that the drug actually works by blocking an enzyme (thymidylate synthase) that the cells need for survival.

Neufeld's group recently found that the enzyme nitric oxide synthase 2 (NOS - 2), which produces toxic levels of the gas nitric oxide, is active in the eyes of rats that have their eyes» drainage channels blocked, causing an artificial form of glaucoma.

The study, which appears online October 29 in the journal Science Signaling, describes a previously uncharacterized interaction between GRK2 and an enzyme called endothelial nitric oxide synthase (eNOS), in which the two enzymes attempt to block one another's activity, with different outcomes on heart function.

Galactinol synthase (GolS) is an enzyme needed to produce one these important sugars called galactinol.

She discovered that the enzyme made by the phytoene synthase was the «bottleneck» in production.

«We discovered a very interesting gene that's called lycopaoctaene synthase, or LOS.

When cells are deprived of oxygen and sugars, a mitochondrial complex that usually produces ATP, called ATP synthase, switches to consuming it, a state that can be harmful to an already starving cell.

How lithium stabilises mood is poorly understood but when the scientists investigated how it prolongs the lives of flies, they discovered a new drug target that could slow aging — a molecule called glycogen synthase kinase - 3 (GSK - 3).

ATPIF1 interacts with ATP synthase to shut it down and prevent it from consuming the mitochondrion's dwindling ATP supply but, in the process, also worsens the mitochondrion's membrane potential

In 2000, Australian farmers for the first time planted varieties of canola with resistance to acetolactate synthase - inhibiting herbicides.

The journal Plant Physiology recently published their study, «Tandem Amplification of a Chromosomal Segment Harboring 5 - Enolpyruvylshikimate -3-Phosphate Synthase Locus Confers Glyphosate Resistance in Kochia scoparia.»

Adenosine triphosphate (ATP) synthase contains a rotary motor involved in biological energy conversion.

FASN encodes the enzyme fatty acid synthase, which is responsible for making fatty acids — an essential source of energy.

They identified the molecular target of J147 as a mitochondrial protein called ATP synthase that helps generate ATP - the cell's energy currency - within mitochondria.

Further experiments revealed that modulating activity of ATP synthase with J147 changes the levels of a number of other molecules - including levels of ATP itself - and leads to healthier, more stable mitochondria throughout aging and in disease.

The team is already performing additional studies on the molecules that are altered by J147's effect on the mitochondrial ATP synthase - which could themselves be new drug targets.

Research has shown that glycogen synthase kinase (GSK) 3β is an enzyme that plays a major role in the development of AKI.

Until now, most studies of rose fragrance have focused on a biosynthetic pathway that generates pleasant - smelling alcohols, known as monoterpenes, using specific enzymes called terpene synthases.

Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + / calmodulin - dependent type I NO synthase of about 150 kilodaltons.

Some scientists have argued that terpene synthases are the sole route to the production of fragrant monoterpenes in plants.

For many years, it was thought that the breadth of ceramide synthases present in cells represented redundant functions for this family of enzymes.

Some Alzheimer's researchers have cited evidence indicating that free - floating amyloid helps produce the corrupted p - tau via a chain of reactions that centers around GSK3 (Glycogen synthase kinase 3), an enzyme that arms tau with phosphorous, turning it into a potential biochemical assassin.

The bacteria make polyketides with the assistance of a family of enzymes called polyketide synthases (PKSs).

This illustration is a model of Chl f synthase, potentially a ChlF dimer, based on the known X-ray structure of the core of the Photosystem II reaction center.

Sitting inside the Schwann cells, an enzyme known as fatty acid synthase (FASN) acts as a central «switch» in the process of synthesising lipids.

Pictured are isolated adult mouse cardiomyocytes labeled for dystrophin (red), neuronal nitric oxide synthase (nNOS)(green), and nuclei (blue).

This study also presents the structure - based mechanisms for substrate specificities of various PHA synthases from different classes.

Thus, the characteristics and molecular mechanisms of PHA synthase were under a dark veil.

In two papers published back - to - back in Biotechnology Journal online on November 30, 2016, a Korean research team led by Professor Kyung - Jin Kim at Kyungpook National University and Distinguished Professor Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) described the crystal structure of PHA synthase from Ralstonia eutropha, the best studied bacterium for PHA production, and reported the structural basis for the detailed molecular mechanisms of PHA biosynthesis.