Chairs: Stanly Rockson, Stanford University and Kari Alitalo, University of Helsinki Guillermo Oliver, Northwestern University Transcriptional profiling of lymphatic endothelial cells Melody Swartz, University of Chicago Immune implications
of lymphangiogenesis in inflammation
Glycolytic metabolism and VEGFR3 signaling are required
for lymphangiogenesis Joanna Chen, Hampton University
Local induction of
lymphangiogenesis with engineered fibrin - binding VEGF - C promotes wound healing by increasing immune cell trafficking and matrix remodeling Witold Kilarski, University of Chicago
Therapeutic stimulation of
cardiac lymphangiogenesis — protein vs. gene therapy approaches post-MI Ebba Brakenhielm, Rouen University
The role of polyunsaturated fatty acid - derived epoxides and diols in angiogenesis and
lymphangiogenesis Giorgia Ciliberti, Goethe University Frankfurt
Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye,
Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University
These findings led us to investigate the roles of S1P in tumor microenvironment, and found that S1P promote not only angiogenesis, but
also lymphangiogenesis and lymph node metastasis of breast cancer (Nagahashi M et al, Cancer Research 2012).
Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and
lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases
Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada, A, Zhao R, Milstien S, Zhou H, Spiegel S, and Takabe K. Sphingosine -1-phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and
Lymphangiogenesis.