Movement across the CD169 + macrophage layer into the sinus is promoted by S1pr1 and
lymphatic endothelial cell - derived S1P.
We demonstrate a novel outcome of S1P - mediated regulation of lymphocyte trafficking, whereby deletion of Spns2, either globally or in
a lymphatic endothelial - specific manner, creates a circulating lymphopenia and a higher percentage of effector T cells and natural killer (NK) cells present in the lung.
Chairs: Stanly Rockson, Stanford University and Kari Alitalo, University of Helsinki Guillermo Oliver, Northwestern University Transcriptional profiling of
lymphatic endothelial cells Melody Swartz, University of Chicago Immune implications of lymphangiogenesis in inflammation
Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and
lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University
Investigating the effect of spatially varying wall shear stress on
lymphatic endothelial cell alignment and transcriptional regulation Eleftheria Michalaki, Stanford University
Syk and Src Family Kinases Regulate C - type Lectin Receptor 2 (CLEC - 2)- mediated Clustering of Podoplanin and Platelet Adhesion to
Lymphatic Endothelial Cells.
Intracellular uptake of macromolecules by brain
lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster
Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells.
The team used light and electron microscopy to show that
lymphatic endothelial cells, which line the interior surface of the lymph node capsule, contain a number of channels that penetrate the whole thickness of the cells.
Not exact matches
These proteins most closely resembled those made by
endothelial cells in the
lymphatic system, not the proteins made by macrophages or other immune cells.
These scientific goals guide our efforts at determining the role and mechanisms of the stromal cells, including the fibroblasts,
endothelial and
lymphatic elements, the matrix and the inflammatory / immune cells as critical targets for therapeutic intervention.
At the cellular level this changes the tension on the filaments of the
endothelial cells of the initial
lymphatic capillaries, facilitating their opening and closing.