Investigating the effect of spatially varying wall shear stress
on lymphatic endothelial cell alignment and transcriptional regulation Eleftheria Michalaki, Stanford University
Intracellular uptake of macromolecules by
brain lymphatic endothelial cells during embryonic development Stefan Schulte - Merker, Westfälische Wilhelms - Universität Münster
Chairs: Stanly Rockson, Stanford University and Kari Alitalo, University of Helsinki Guillermo Oliver, Northwestern University Transcriptional profiling
of lymphatic endothelial cells Melody Swartz, University of Chicago Immune implications of lymphangiogenesis in inflammation
Although CCL20 is not abundantly expressed in LNs, it is expressed in
LN lymphatic endothelial cells (LECs) at levels more than 100-fold higher than other LN lymphoid stromal cells (Figure 4A).
The team used light and electron microscopy to show that
lymphatic endothelial cells, which line the interior surface of the lymph node capsule, contain a number of channels that penetrate the whole thickness of the cells.
Movement across the CD169 + macrophage layer into the sinus is promoted by S1pr1 and
lymphatic endothelial cell - derived S1P.