Sentences with phrase «lymphocyte activation»

He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy.

CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.

Prostaglandin E2 inhibits B lymphocyte activation by a cAMP - dependent mechanism: PGE - inducible regulatory proteins.

Research Interests: Lymphocyte activation; Signal transduction; Membrane - cytoskeletal dynamics; Lymphoma; Autoimmunity; Inflammation.

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl - b.

Mechanisms of Lymphocyte Activation and Immune Regulation XI, 139 — 148.

Since 2000 Head of Lymphocyte Activation Unit Division of Immunology, Transplantation and Infectious Diseases Program in Immunology, Bio-Immuno-gene therapy of Cancer, IRCCS Ospedale San Raffaele, Milan, Italy 1998 - 1999 Research Associate Department of Molecular Biology and Functional Genomic, IRCCS Ospedale San Raffaele, Milan, Italy 1993 - 1998 Postdoctoral Associate Department of Microbiology University of Minnesota, Medical School Minneapolis, MN, USA 1991 - 1992 Department of Pharmacology, New York University, New York, USA 1989 - 1991 Department of Biomedical Science and Oncology, Turin, Italy 1988 - 1989 Research Fellow Department of Biomedical Science and Oncology, Turin, Italy 1989 - 1992 Ph.D. student in Molecular Oncology 1986 - 1988 Undergraduate student Department of Biomedical Science and Oncology, Turin, Italy

Since 1999 she is the Head of the Lymphocyte Activation Unit within the Division of Immunology, Transplantation and Infectious Diseases at IRCCS Ospedale San Raffaele in Milan, Italy.

Researchers think it acts on another gene called lymphocyte activation gene - III, located at the other end of the same chromosome.

Not exact matches

She is widely considered to be the international authority on the development and activation of lymphocytes in the immune system.

«Our study showed that an»em pty» milk protein supports the activation of Th2 lymphocytes and so initiates an allergic chain reaction,» says Hufnagl.

The scientist explains that the nanoparticle works as a bridge of antitumor activation between tumor cells and T lymphocytes.

Abraham Kupfer describes the three - dimensional structure of supramolecular activation clusters (SMACs), the interface between an antigen presenting cell and a lymphocyte (including key molecules the T cell receptor and the major histocompatibility complex), [i] later coined the immunological synapse and further elucidated by Arash Grakoui, Michael Dustin, Paul Allen, and Andrey Shaw.

Signal transduction through the T - lymphocyte CD4 receptor involves the activation of the internal membrane tyrosine - protein kinase p56lck.

Interestingly, analysis of lymphocytes from breast cancer patients showed that signatures of NK cell activation predicted relapse - free survival post initial surgery.

They include reduced lymphocyte repertoire, increasing clonality and increasing autoreactivity.5, 7,8 Recent work has focused on intrinsic cell defects, which alter T cell activation threshold, induction of cellular senescence and differentiation into short - lived effector or long - lived memory cells.

For example, one could stain for cellular markers and activation markers to infer the activity status of T lymphocytes

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Stress - surveillance contributes to anti-neoplastic immunity through the activation, on lymphocytes, of the NKG2D receptor that recognizes ligands (NKG2D - L) expressed on cancer cells.

Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy.

HTLV - 2 Tax immortalizes human CD4 + memory T lymphocytes by oncogenic activation and dysregulation of autophagy % U http://www.jbc.org/content/early/2012/08/13/jbc.M112.377143.short.

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation.

Accumulation of MCMV - specific CD8 + T lymphocytes was seen in all organs tested and was associated with continuous activation of specific CD8 + T lymphocytes, primarily within lymph nodes.

Recent studies indicated that autoimmune diseases like Type 1 Diabetes (T1D) are induced by genetic or environment - induced alterations of immune regulatory pathways whose function is to avoid or limit the activation / expansion of self - reactive T lymphocytes.

Cutting Edge: Class II Transactivator - Independent Endothelial Cell MHC Class II Gene Activation Induced by Lymphocyte Adhesion

Excessive activation of lymphocytes (a form of white blood cells) are thought to be responsible for the short epidermal cell cycle that results in hyperproliferation of skin tissues.

Cruciferous vegetables — broccoli, Brussels sprouts, kale, cauliflower, cabbage — contain a phytonutrient that is transformed by our stomach acid into the key that fits into the Ah receptor locks on our intraepithelial lymphocytes, leading to their activation.

APS (also known as astragalus polysaccharide) has been shown to activate the immune system by enhancing the transformation of T lymphocytes (a sub-type of white blood cells, crucial in the regulation of immune responses), as well as the activation of B lymphocytes (which produce antibodies that are used to attack invading bacteria, viruses, and toxins) and dendritic cells, which trigger immune reactions to toxins.

It is theoretically possible that this activation might include autoreactive lymphocytes, and as alum is very effective at stimulating antibody responses, the activation of B cells and their particular helper T cells (Th2 cells) might readily arise....»