Sentences with phrase «lymphocyte development»

The microRNA miR - 181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

His laboratory at MGH postulated and provided evidence for the first ligand - independent signaling model during lymphocyte development, now a widely accepted mechanism for both pre-B receptor and pre-T receptor signaling.

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

Maria Schreiber: IL - 7 effects on lymphocyte development and function in transplantation relevant models

Title: Hes1 Is a Critical but Context - Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation Authors: Wendorff AA, Koch U, Wunderlich K, Wirth S, Dubey C, Brüning JC, MacDonald HR, Radtke F Date: November 2010 Publication Details: Immunity 18 Nov 2010; 33 (5): 671 - 84

Dr Véronique Azuara has worked for several years in the field of developmental biology and genetics moving from lymphocyte development (PhD training at the Pasteur Institute — Paris) to epigenetic studies (post-doctoral training at the MRC / Clinical Sciences Centre — London) to explore how chromatin shut down contributes to lineage restriction and maintenance of cell fate identity through development.

Targeted disruption of IRF - 1 or IRF - 2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

Lu, R., Medina, K. L., Lancki, D. W. & Singh, H. IRF - 4, 8 orchestrate the pre-B-to-B transition in lymphocyte development.

Not exact matches

She is widely considered to be the international authority on the development and activation of lymphocytes in the immune system.

Researchers uncovered the following pathway: gut bacteria stimulate intestinal B lymphocytes to release interleukin (IL)-10 that, in turn, induces development of regulatory T lymphocytes that prevent excessive inflammatory responses and limit immune - mediated disease.

This mouse study shows that IL - 10 and IL - 27, which are secreted by B lymphocytes, regulate development of regulatory T lymphocytes.

The overlap and density of these lymphocytes within the tumor and peripheral blood offer novel prognostic biomarkers for this deadly disease,» adds Richard Koya, MD, PhD, Associate Director of the Roswell Park Center for Immunotherapy and Director of the Institute's Vector Development and Production Facility.

CXCR4, along with its natural ligand CXCL12, plays a critical role in normal B cell, cardiovascular, and cerebellar development, though T lymphocytes appear to develop normally in cxcr4 − / − mice [51].

Research Focus: My research in the laboratory of Mitchell Kronenberg has concentrated on examining the development and function of Vα14i NKT cells, which are T lymphocytes with a number of unique properties.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

For example, non-homologous end - joining is involved in the development of lymphocytes in resolving recombination intermediates i.e., DNA strand breaks (DSBs) that occur during V (D) J recombination.

The successful applicant will join the laboratory of Dr Rahul Roychoudhuri within the Lymphocyte Signalling and Development ISP.

Our company focuses on the development of innovative immunotherapies for cancer based on genetically engineered lymphocytes and cellular components of the tumor microenvironment.

Myeloid cells are cells that would have become other blood cells (white blood cells other than lymphocytes, red blood cells or platelets) under normal development.

Loss of prolyl hydroxylase - 2 in myeloid cells and T - lymphocytes impairs tumor development.

Dr. Ziaur S.M. Rahman, assistant professor of microbiology and immunology, is working to answer what factors drive the development of B lymphocyte groups without the presence of a pathogen.

Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults