Sentences with phrase «lymphocyte response»

Adequate zinc status is essential for T - cell division, maturation and differentiation; lymphocyte response to mitogens; programmed cell death of lymphoid and myeloid origins; gene transcription; and biomembrane function.

So with the ELISA, it's also looking at T - cell lymphocyte response and you're not gonna get that picked up on Cyrex.

Role in suppression of cytotoxic T lymphocyte response and viral persistence.

Subsequent studies in animal models that are thought to mimic the human experience indicate RSV inactivated vaccine induces an increased CD4 + T lymphocyte response, primarily of Th2 cells and the occurrence of immune complex depositions in lung tissues [32], [42], [43].

The immune responses will be evaluated in the different species by measuring influenza antigen - specific IgG / IgA and IgM, neutralising antibodies and antibodies inhibiting hemagglutination and antigen specific lymphocyte responses and cytokine secretion profiles by advanced flow cytometry.

Antigen specific lymphocyte responses and cytokine secretion profiles will be assessed by advanced flow cytometry.

DNA methyltransferase inhibition upregulates MHC - I to potentiate cytotoxic T lymphocyte responses in breast cancer.

We hypothesize that both the quality and timing of DENV - specific antibody and T lymphocyte responses influence whether their overall effect is beneficial (controlling DENV replication and reducing the severity of illness) or harmful (creating a «cytokine storm» leading to plasma leakage).

Not exact matches

The more immediate allergic response is anaphylaxis, which is moderated by antibodies made by B lymphocytes.

CD4 cells (also known as T4 or helper T cells) are lymphocytes (a type of white blood cell), which are important in immune responses.

He said that the most exciting arenas of immunology today include new strategies for vaccines and studies of regulatory T lymphocytes and the innate immune response, which is essentially the most general form of attacking pathogens.

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

Natural killer (NK) cells are lymphocytes involved in antimicrobial and antitumoral immune responses.

Researchers uncovered the following pathway: gut bacteria stimulate intestinal B lymphocytes to release interleukin (IL)-10 that, in turn, induces development of regulatory T lymphocytes that prevent excessive inflammatory responses and limit immune - mediated disease.

Under the influence of HIF, B - lymphocytes, which usually have a crucial role to play in the excessive immune response, start to produce the regulating messenger substance Interleukin 10, inhibiting the inflammatory process.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

Lymphocytes in the grafts of undifferentiated iPS cells were also expressing relatively high levels of genes known to be involved in hostile immune responses.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

By characterizing memory lymphocytes from ZIKV - infected patients, we dissected ZIKV - specific and DENV — cross-reactive immune responses.

The scientists conclude that the study reveals an essential function for CTCF in the orchestration of transcriptional changes during the terminal differentiation of B lymphocytes and advances understanding of the mechanisms that regulate the immune response.

«That protection was probably caused by specific T - lymphocytes and antibody responses to the parasites in the liver,» Professor Peter Kremsner explained.

Although GMCSF is mostly known for its role in inflammation, Dr. Merad's laboratory discovered that GM - CSF is produced in the normal gut by specialized cells called innate lymphocyte cells (ILCs) in response to microbiota signals.

Still, there was the problem of Sharp's T cells — the white blood cells, or lymphocytes, that unleash a powerful immune response against pathogens like HIV.

Infections set off the release of cytokines, which are proteins that trigger inflammatory responses, including a rush of lymphocytes and the sacrifice of virus - compromised cells.

«Our research shows that the presence of lymphocytes before administering chemotherapy could predict a positive response to platinum - based therapy.»

Platinum - based therapies are being tested in clinical trials for triple - negative breast cancer, and evaluation of tumor - infiltrating lymphocytes is an important factor in determining response to this treatment.

Interestingly, recipients of CD8 + T lymphocytes failed to mount DTH responses to BALB / c alloantigens (Figure 4), even though similar panels of mice rejected 95 % of their BALB / c corneal allografts (Figure 2B).

Although originally described as a cytokine promoting Th1 responses, our work has uncovered diverse roles of this cytokine in the responses of both pathogenic T lymphocytes and Treg.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

Bertani G, Santoleri L, Ferri U, Marenco P, Grillo G, Zucchetti E, Forno B, Lando G, Scarpati B, Cairoli R, Rossini S, Cesana C. Response of steroid - refractory chronic graft - versus - host disease to extracorporeal photopheresis correlates with the dose of CD3 + lymphocytes harvested during early treatment cycles.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and correlated inversely with disease severity.

Charles Janeway introduces the hypothesis that «components of the innate [immune] system, especially antigen - presenting cells such as DCs, required the microbial stimuli contained in [adjuvants] to become activated and acquire the capacity to induce productive responses from antigen - specific lymphocytes.

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.

Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex.

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

The researchers tested whether stromal tumor infiltrating lymphocytes (TILs) and other immune cells might predict responses to therapy in a set of 30 HER2 - positive breast cancer tissues treated with TCHP (26 patients) or with TCH without pertuzumab (4 patients).

Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor.

The first Phase 1 study of this vaccine in a malaria - exposed population found it to have promising safety and tolerability profiles in adults in Bandiagara, Mali, and to elicit dose - dependent anti-AMA1 antibody responses [17] as well as IL - 5 production and lymphocyte proliferative responses [22].

«Recently, analyses of patients who received checkpoint blockade identified neutrophil - to - lymphocyte ratio < 3 and normal lactate dehydrogenase as positive predictors of response; however, in our lymphodepleted patient population, neither separated patients who achieved responses from those who did not clearly enough to warrant use as an inclusion criterion,» the researchers wrote.

While cytotoxic lymphocytes are known to produce anti-tumor activity, T cell response can be modulated by activating and inhibitory co-receptors.

Major CFS symptom relief during cancer chemotherapy in a patient with synchronous CFS and lymphoma spurred a pilot study of B - lymphocyte depletion using the anti-CD20 antibody Rituximab, which demonstrated significant clinical response in three CFS patients.

In diabetic non ‐ obese diabetic (NOD) mice, adipose - derived MSCs (ASCs) have been shown to decrease hyperglycemia and insulitis through attenuation of the Th1 immune response and expansion of T regulatory lymphocytes [3].

Dr. Liang Cao and his team at the National Cancer Institute investigated whether this biomarker could be used to identify patients with HPV16 - or HPV18 - positive metastatic cervical cancer and to assess the patient's response to tumor - infiltrating lymphocyte (TIL) immunotherapy.

A targeted approach will develop vaccines that can reverse these age - related changes in T - cell responses, particularly the functions of cytotoxic T lymphocytes.

This is often enough to halt the infection but the second part of the immune response is adaptive immunity, when dendritic cells activate T lymphocytes and trigger a cascade of immune reactions, such as the formation of antibodies and killer cells that clear the infection from the body and form a memory of the invading pathogen.

He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.

Additionally, splenocytes of recipient animals were used as responder cells in mixed lymphocyte reactions and ELISPOT to determine responses to donor alloantigen.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.