The investigators also found that there was a decrease in blood vessels and
lymphocytic cell infiltration, both in AA98 - treated and V1q - treated mice, whereas a more significant decrease was observed in the combination treatment group.
Lymphocytic thyroiditis, probably immune - mediated, is characterized histologically by a diffuse
infiltration of the gland by lymphocytes, plasma
cells, and macrophages and results in progressive destruction of follicles and secondary fibrosis.