Sentences with word «lymphoid»

«This study fundamentally changes our mindset about how HIV causes massive cell death, and puts the spotlight squarely on the infected cells in lymphoid tissues rather than the free virus,» says senior author Warner C. Greene, MD, PhD, director of the Gladstone Institute of Virology and Immunology.

Even at this stage, measuring the number of innate lymphoid cells in the blood makes it possible to provide a prognosis of the effects of treatment.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

Facilitate cross-disciplinary research programs focused on understanding the biological mechanisms of lymphoid cancers for the development of novel therapeutic treatments for these cancers.

Further investigation revealed that the increased susceptibility was due to a reduction in production by the innate lymphoid cells of IL - 22, a protein that plays a key role in the intestinal immune response.

Currently, most genetic mutations associated with lymphoid cancers have been identified.

In antibody - free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody - competent mice (and enhanced their susceptibility to some infections), and titers in secondary lymphoid organs were 10 to 100 times lower than in antibody - competent mice.

Hypertrophy, hyperplasia, and infectious virus in gut - associated lymphoid tissue of mice after oral inoculation with simian - human or bovine - human reassortant rotaviruses.

In another case, a 12 - week old Greyhound was also afflicted with acute lymphoid leukemia.

Basically, lymphoma is a malignant cancer that involves lymph nodes and organs with lymphoid tissues, such as the liver, spleen, gastrointestinal tract and skin.

B cells are produced in the bone marrow and migrate to the spleen and other secondary lymphoid tissues for maturation.

Feline leukemia virus (FeLV) causes cancers of the blood and lymphoid system in cats.

The purpose of this newsletter is to provide a brief summary of the projects underway throughout our Centre for Lymphoid Cancer program, the people that work on them, and useful information on upcoming events.

With lymphoid tumors in dogs, there is usually generalized symmetrical swelling of the lymph nodes in addition to the cancer in the spleen.

Interestingly, CD8 and NK cells are unable to traffic into lymphoid follicles.

Unlike investigators before them, this team focused on T cells from lymphoid organs such as the spleen and lymph nodes.

«We could visualize hot spots of infection within lymphoid tissue, which has millions of cells moving dynamically within the tissue,» says Mr. Law.

The workshop will also discuss other well described syndromes such as Li - Fraumeni germline TP53 mutations as well as inherited lymphoid malignancies and pedigrees of high interest that have no known genetic predisposition alleles identified.

Lymphoma is cancer of the lymph nodes or other lymphoid tissue such as the spleen or tonsil.

- Chimeric Antigen Receptor - Modified T Cells for Acute Lymphoid Leukemia; Stephan A. Grupp MD, PhD, University of Pennsylvania Children's Hospital of Philadelphia.

The primary lymphoid organs include the bone marrow and thymus.

They found that the precursors of B cells, such as hematopoeietic stem cells and common lymphoid progenitors, had clear patterns of Xist RNA on the inactive X chromosome.

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector.

For example, most of the immune system is located in the gut — about 70 % of it — through something called the Gut Associated Lymphoid Tissue (GALT).

Histological lesions are lymphoid depletion, thickened alveolar septa, proliferation of respiratory epithelium, swelling of transitional cell epithelium of the bladder, degenerative changes in the adrenal gland, necrosis and cystic degeneration of ameloblasticepithelium, perivascular lymphoplasmacytic infiltration of CNS.

To have scientists, translational researchers, and clinicians «hear it here first» when it comes to the next big thing in the management of lymphoid diseases.

Analysis of Immunoglobulin and T Cell Receptor Gene Rearrangement in the Bone Marrow of Lymphoid neoplasia Using BIOMED - 2 Multiplex Polymerase Chain Reaction.

Schallenberg S, Tsai PY, Riewaldt J, Kretschmer K. Identification of an immediate Foxp3 − precursor population to Foxp3 + regulatory T cells in peripheral lymphoid organs of non-manipulated mice.

Using lymphoid tissue infected with HIV, the scientists compared cell death rates between cell - to - cell and cell - free virus transfer.

Although CCL20 is not abundantly expressed in LNs, it is expressed in LN lymphatic endothelial cells (LECs) at levels more than 100-fold higher than other LN lymphoid stromal cells (Figure 4A).

Diversification of myeloid and lymphoid pathways follows this stage.

Paediatric and Adolescent Elevated Conjunctival Lesions in the Plical Area: Lymphoma or Reactive Lymphoid Hyperplasia?

Our molecular tests can be the difference in distinguishing between benign and malignant lymphoid proliferations.

There are several types of chronic canine leukemia defined as: - Granulocytic (neutrophil) canine leukemia - Lymphobastic canine leukemia - Eosinophilic canine leukemia - Lymphoid canine leukemia

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

What is the effect of the HIV - 2 accessory protein Vpx on HIV infectivity and the cell death pathway in lymphoid CD4 T cells?

Another form of lymphoma affects the internal lymph nodes or tissues that are made of similar lymphoid material such as the liver or spleen.

In contrast, examination of the same section of small intestine after the infant is born and has begun breast - feeding reveals proliferating, mature epithelium with enterocyte differentiation and abundant lymphoid tissue.

Consistent with this idea, microscopic examination of fetal small intestine before birth reveals immature epithelium and sparse lymphoid cells.

The researchers discovered that these specialised killer T cells, called follicular cytotoxic T cells, can enter hiding spots inside lymphoid tissue, where viruses can hide on treatment.

Future studies using drugs that better penetrate the entire lymphoid tissue compartment should provide a more complete picture of how viral reservoirs are maintained and help pave a promising path to a cure, according to the authors.

This block is caused by mutations of the gene encoding the γc cytokine receptor subunit of interleukin - 2, -4, -7, -9, and -15 receptors, which participates in the delivery of growth, survival, and differentiation signals to early lymphoid progenitors.