Sentences with phrase «lymphoid cells in»

Adult male mice also started off with fewer of the lymphoid cells in the lungs than adult females, the researchers found: Female mice had about 1 1/2 times as many of these immune cells as males.

Innate lymphoid cells in the intestine of healthy mice.

Even at this stage, measuring the number of innate lymphoid cells in the blood makes it possible to provide a prognosis of the effects of treatment.

The researchers deleted the HIC1 gene in certain innate lymphoid cells in the mouse intestine and found that this increased the susceptibility of the mice to infection with the bacterium Citrobacter rodentium.

Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen - treated macrophages and lymphoid cells in cell culsters for only a finite time.

Not exact matches

But the bottom line is that about two thirds of all T cells reside in the lymphoid tissue of the gut, where the virus spreads after exposure, even before it shows up in blood.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

«Their properties and the ability to induce these cells by vaccination provide a tremendous opportunity to target and reduce the viral reservoir in lymphoid tissues.»

When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the lymphoid tissue that are responsible for initiating immune responses.

«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory diseases,» suggests Sonnenberg.

Further investigation revealed that the increased susceptibility was due to a reduction in production by the innate lymphoid cells of IL - 22, a protein that plays a key role in the intestinal immune response.

New research shows that all - trans - retinoic acid (atRA), the active form of vitamin A, regulates immune system responses in the mouse intestine by controlling expression of the protein HIC1 in cells known as innate lymphoid cells.

Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.

«These findings will make it possible to significantly improve the quality of treatment of rheumatoid arthritis in future with the help of innate lymphoid cells,» says Dr Ramming.

Previous research has shown that atRA, produced from dietary vitamin A by some intestinal cells, helps maintain this balance in mice by regulating the activity of innate lymphoid cells.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

This temporary colonization of E.coli in the mother affected the immune system of her offspring; after birth, the offspring harbored more innate lymphoid and mononuclear cells in their intestines compared to mice born to microbe - free pregnant mothers.

The research team, a collaborative partnership between the groups of Professor Gabrielle Belz of Melbourne's Walter and Eliza Hall Institute, and Professor Eric Vivier at the Centre d'Immunologie de Marseille - Luminy, France, found that innate lymphoid cells (ILCs) are crucial for protecting against bacterial infection in people with compromised immune systems.

In further tests, the researchers determined that testosterone was preventing the innate lymphoid cells from multiplying in the lungIn further tests, the researchers determined that testosterone was preventing the innate lymphoid cells from multiplying in the lungin the lungs.

In humans, Newcomb and her colleagues measured the number of group 2 innate lymphoid cells circulating in the blood of adults with moderate to severe asthmIn humans, Newcomb and her colleagues measured the number of group 2 innate lymphoid cells circulating in the blood of adults with moderate to severe asthmin the blood of adults with moderate to severe asthma.

When hypoxia occurs, the activity of CD45 — a protein found in myeloid and lymphoid cells — increases.

Early discoveries led researchers to home in on the hematopoietic system, the organs that produce the two kinds of blood cells, lymphoid and myeloid cells.

Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood into lymphoid tissue, where they learn to recognize and fight pathogens.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

Induction of rotavirus - specific memory B cells in gut - associated lymphoid tissue after intramuscular immunization.

Distribution of rotavirus - specific memory B cells in gut - associated lymphoid tissue after primary immunization.

Tissue - cultured corneal cells were used for in vitro studies rather than the usual lymphoid cells since corneal cells are the relevant target cells in vivo during corneal allograft rejection.

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

Chimeric antigen receptor - modified T cells in chronic lymphoid leukemia.

The frequency of CD39highCD8 + T cells increased with tumor growth but was absent in lymphoid organs.

lymphocyte - a white blood cell present in the blood, lymph and lymphoid tissue that is essential in immune defense.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Research Focus: My research focuses on the role of the herpesvirus entry mediator (HVEM) of by Innate Lymphoid Cells (ILC) and intraepithelial lymphocytes (IEL) in the Intestine.

Schallenberg S, Tsai PY, Riewaldt J, Kretschmer K. Identification of an immediate Foxp3 − precursor population to Foxp3 + regulatory T cells in peripheral lymphoid organs of non-manipulated mice.

In pathological conditions, MSCs migrate preferentially into lymphoid organs, allografts, injured and / or inflammatory tissue sites after systemic transfusion, where they interact with the activated immune cells and modulate their function 51, 52.

[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector.

T cells exert their actions in two ways, either through direct cell - cell contact which involves transmembrane proteins present on both the T cell and interacting cell, or by the secretion of soluble proteins termed cytokines which have receptors on many lymphoid and some non-lymphoid cell types.

The reservoir of latent HIV in the gut is poorly understood, especially because resting memory T cells in the gut are different than those in lymphoid tissues and blood.

What's more, the discovery of such a fundamental difference in the biology of blood and lymphoid tissue CD4 T cells opens the door to retesting drugs in lymphoid tissue that were deemed ineffective in blood cells.

In a curious twist resembling cellular alchemy, when blood T cells are cultured with lymphoid tissue from the tonsils or spleen, the blood T cells begin acting like lymphoid tissue T cells, becoming more activated and more susceptible to abortive infection and death by pyroptosis.

10:45 - 11:45 AM Innate lymphoid cells: Their role in inflammatory diseases Harm HogenEsch, Purdue University

Leukemia that starts in lymphoid cells — which make different types of white blood cells — is called lymphocytic or lymphoblastic leukemia.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

His group defined a functional niche for B cells (around sinusoids in the bone marrow), identified the first two mutants that abrogate marginal zone B lymphocyte development, developed the concept of a follicular versus marginal zone B lymphoid cell - fate decision, and discovered two new defined stages of peripheral B cell development, the marginal zone precursor (MZP) B cell, and the Follicular type II B cell.

This hematoxylin and eosin stained slide of a surgically removed (resected) primary pancreatic tumor shows a cluster of immune cells (lymphoid aggregate) observed next to a pancreatic tumor lesion in a patient treated with a GM - CSF vaccine 2 weeks before surgical removal of the primary tumor.

The scientists say the latest findings, published in the journal Cell Host & Microbe, should spark greater use of lymphoid tissue T cells to study the pathogenic effects of HIV.

PTPN22 is involved in the formation of a key protein known as lymphoid tyrosine phosphatase (LYP), which helps control the activity of T and B cells in the immune system.

Lymphoid cells are different from the other somatic cells in the body.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters