To have scientists, translational researchers, and clinicians «hear it here first» when it comes to the next big thing in the management of
lymphoid diseases.
Amplification of the JAK2 locus has been described in Hodgkin disease and mediastinal B - cell lymphoma, 18,19 and biallelic inactivating mutations in suppressor of cytokine signaling - 1 (SOCS - 1), a negative regulator of JAK2, have been identified in mediastinal B - cell lymphoma.20 Genomic analysis of JAK2 and of other JAK - STAT pathway members may lead to the identification of mutations of the JAK - STAT pathway in
lymphoid diseases and other malignancies.
Not exact matches
The research suggests there are more people infected in
lymphoid tissues, who may never develop the
disease but could still infect others via blood transfusions or organ donations
The
disease originates in a
lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other
lymphoid organs but also other tissues.
«Although it's still early days for this line of research, these findings provoke the hypothesis that MHCII + innate
lymphoid cells may be an important pathway to therapeutically target in the treatment of some chronic inflammatory
diseases,» suggests Sonnenberg.
Using mice bred to lack some types of
lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that
lymphoid cells were not the perpetrators of kidney
disease.
The researchers went on to identify the immune networks underlying IL - 33's harmful effects and discovered that this molecule activates immune cells called type 2 innate
lymphoid cells (ILC2), which had never before been linked to liver
disease.
Canadian Society for Immunology (CSI) Symposium Innate
Lymphoid Cells and Inflammatory
Disease Monday, May 7, 3:45 PM — 5:45 PM, Room 10AB Chairs: Kelly McNagny, Univ. of British Columbia Arthur Mortha, Univ. of Toronto
10:45 - 11:45 AM Innate
lymphoid cells: Their role in inflammatory
diseases Harm HogenEsch, Purdue University
Altogether, these results indicate that the xenograft grew from the patient's Epstein - Barr virus - infected B -
lymphoid cells and could be assimilated to posttransplant lymphoproliferative
disease.
«These results drive home that HIV is a
disease of
lymphoid tissues, not blood,» says senior author Warner C. Greene, MD, PhD, director of the Gladstone Institute of Virology and Immunology.
Included patients had three subtypes of
disease, mucosa - associated
lymphoid tissue, nodal, and splenic.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis,
lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular
diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's
disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular
diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative
diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
Lymphoid neoplasms are cancers of the immune system, which afflict both adults and children, and account for 6 - 10 % of all neoplastic
diseases.
Hodgkin lymphoma (HL) is a lymphoproliferative
disease arising in the
lymphoid tissue, which is characterized by Reed - Sternberg cells.
Lymphoid tissue can be found throughout your pet's body and is made up of lymphocytes, white blood cells that work to protect the body from
disease.
The canine tonsils are
lymphoid tissue and therefore, are important in fighting
diseases.
LEUKOCELL 2 is a multiple viral antigen vaccine for vaccination of healthy cats 9 weeks of age or older as an aid in preventing persistent viremia,
lymphoid tumors caused by feline leukemia virus (FeLV) and
diseases associated with FeLV infection.
In a letter to Veterinary Times during July 1999, veterinarian Lyn Thomson responded, «This would indicate that veterinarians must consider and report the whole range of immune mediated
diseases post vaccination, including flea allergy, atopic dermatitis, dietary hypersensitivity, contact hypersensitivity, asthma, autoimmune
diseases, lymphoma,
lymphoid leukaemia, multiple myeloma, plasmcytoma, hisiiocytoma, thymoma, and immunodeficiency
disease.»
Other, but rarer, causes of metastatic calcification include kidney
disease (this is the most common cause in cats), malignant tumors producing abnormal hormones that increase blood calcium concentrations (e.g. tumors of the
lymphoid system and glands of the anal sac), diabetes mellitus and lung
disease.
The canine tonsils are
lymphoid tissue and therefore important in fighting
diseases.