Lymphoid tissue is a term used to describe a type of tissue in our bodies that helps our immune system fight off infections. It contains special cells called lymphocytes that are responsible for recognizing and attacking harmful bacteria, viruses, and other germs.
Lymphoid tissue is found in places like the lymph nodes, tonsils, and spleen, and plays a vital role in keeping us healthy.
Full definition
Steven Deeks, MD, professor of medicine at UCSF and co-director of the Population and Clinical Sciences Core at CFAR, will investigate how TLR agonists affect the latent reservoir of HIV
in lymphoid tissues in both pre-clinical research and clinical studies of patients already being treated with antiretroviral drugs.
Hypertrophy, hyperplasia, and infectious virus in gut -
associated lymphoid tissue of mice after oral inoculation with simian - human or bovine - human reassortant rotaviruses.
After birth, lymphocytes are found in large numbers in the thymus and lymph nodes, and accumulate in collections
of lymphoid tissue in areas where foreign antigens are likely to enter the body.
Blood cells, which are easier to obtain, do not recapitulate all of the key biology of
lymphoid tissue cells.
Evans» team had previously shown that fever also assists the passage of lymphocytes
into lymphoid tissue, but they hadn't figured out what was happening on a molecular level.
Canine Lymphoma Lymphoma (lymphosarcoma) is a relatively common type of cancer found in dogs and cats which arises
from lymphoid tissue.
«We could visualize hot spots of infection
within lymphoid tissue, which has millions of cells moving dynamically within the tissue,» says Mr. Law.
For example, most of the immune system is located in the gut — about 70 % of it — through something called the Gut
Associated Lymphoid Tissue (GALT).
Future studies using drugs that better penetrate the entire
lymphoid tissue compartment should provide a more complete picture of how viral reservoirs are maintained and help pave a promising path to a cure, according to the authors.
In HIV - infected patients undergoing antiretroviral therapy (ART), ongoing HIV replication in
lymphoid tissues such as the lymph nodes helps maintain stores, or reservoirs, of the virus, a new study funded by the National Institutes of Health suggests.
Basically, lymphoma is a malignant cancer that involves lymph nodes and organs
with lymphoid tissues, such as the liver, spleen, gastrointestinal tract and skin.
The scientists say the latest findings, published in the journal Cell Host & Microbe, should spark greater use of
lymphoid tissue T cells to study the pathogenic effects of HIV.
Lymphocytes constantly circulate through blood vessels within lymph nodes and other lymphoid organs, but only some actually enter
lymphoid tissue by crossing the walls of the vessels, known as high endothelial venules (HEVs).
Distribution of rotavirus - specific memory B cells in gut - associated
lymphoid tissue after primary immunization.
Using
lymphoid tissue infected with HIV, the scientists compared cell death rates between cell - to - cell and cell - free virus transfer.
In contrast, examination of the same section of small intestine after the infant is born and has begun breast - feeding reveals proliferating, mature epithelium with enterocyte differentiation and
abundant lymphoid tissue.
«This study fundamentally changes our mindset about how HIV causes massive cell death, and puts the spotlight squarely on the infected cells in
lymphoid tissues rather than the free virus,» says senior author Warner C. Greene, MD, PhD, director of the Gladstone Institute of Virology and Immunology.
The researchers discovered that these specialised killer T cells, called follicular cytotoxic T cells, can enter hiding spots
inside lymphoid tissue, where viruses can hide on treatment.
The Epstein - Barr virus, for example, is known to be able to dramatically increase the size of
lymphoid tissue during acute infection, and obstructive sleep apnea is fairly common in acute cases of severe infectious mononucleosis.
In this study, researchers demonstrated that continued HIV replication in
lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIV.
Importantly, the researchers used primary
human lymphoid tissues, such as tonsil and spleen to uncover this death pathway.
These and other
lymphoid tissues contain over 98 % of the body's CD4 T cells and represent the major site where the virus reproduces itself.
Modern drugs arrest the progress of the disease, but even after effective treatment the virus remains in the body, lying dormant in cellular reservoirs in the brain and
lymphoid tissues ready to re-activate if the treatment is discontinued.
Also called the lymphatic system, it is comprised of lymphatic vessels that run throughout the body (with the largest vessel being the thoracic duct, which collects a large portion of the body's lymph); lymph nodes, located in the neck, armpit, groin, and inside the center of the chest and abdomen; the tonsils and adenoids, which are collections of
lymphoid tissue similar to lymph nodes; and the spleen and thymus, which are lymphoid organs.
Skin was once thought to be just a physical barrier from the outside world, though the existence of skin - associated
lymphoid tissue shows that it is much, much more.
The secondary lymphoid organs include lymph nodes, spleen, appendix, tonsils, adenoids and Peyer's patches (
lymphoid tissue present in the small and large intestines).
Symptoms
Because lymphoid tissue is found throughout your pet's body, lymphoma can emerge in many different locations, including the lymph nodes, liver, spleen, gastrointestinal tract, and skin.
While lymphoid tissue is common in many parts of the body, cancers typically occur in the lymph nodes, liver, spleen and skin.
Lymphoid tissue normally is found in many different parts of the body including lymph nodes, liver, spleen, gastrointestinal tract and skin.
The virus replicates locally in tissues and rapidly spreads to
local lymphoid tissue (part of the immune system).
In mice with an artificial fever, more lymphocytes (green) adhered to blood vessels (red) in lymphoid organs and crossed the vessels
into lymphoid tissue.
Lymphoma (lymphosarcoma) is a relatively common type of cancer found in dogs and cats which arises
from lymphoid tissue.
[31] Recent studies show that the vaginal mucosa can support T - cell induction in the absence of MALT or
secondary lymphoid tissues, suggesting that the type II vaginal mucosa can itself act as an inductive site for the generation of primary CD8 + T - cell immune responses.
With 70 % of it housed in the Gut
Associated Lymphoid Tissue (GALT) in the intestinal wall, the ecosystem of microbial residents are responsible for influencing the immune gatekeepers such as dendritic cells.
Fostera PCV MetaStim has been demonstrated to aid in preventing viremia, lymphoid depletion and colonization of
lymphoid tissue caused by PCV2, as well as an aid in reducing PCV2 virus shedding.2 - 3 In addition, Fostera PCV MetaStim is backed by the industry - leading 23 - week duration of immunity against PCV2 — three weeks longer than competitors.
The diagnosis of 6 cases were as follows; three diffuse large B cell lymphomas, two mucosa - associated
lymphoid tissue lymphomas and one of other B cell neoplasias.
Mediastinal: The mediastinum is a term used for a special aggregation
of lymphoid tissue in the chest.