Sentences with phrase «lymphoma cell lines hdmyz»

Dr. Steve Suter on canine lymphoma cell lines.

Interestingly, we can observe constitutively active RIPK2 in Hodgkin's lymphoma cell lines HDMYZ, L428 (Fig. 4A), and KMH2 cells (Fig. 4B).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

GCP, a genistein - rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines.

In the laboratory, knocking out PRMT5, or another core component of the splicing machinery in human lymphoma cells lines, also reduced cell viability.

Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055.

Similar results were observed for a third Hodgkin's lymphoma cell line, KMH2 [see (B)-RSB-.

Interferon - alpha Resistance in a Cutaneous T - Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression

Not exact matches

«Patients with non-small cell lung cancer (NSCLC) should receive front line therapy with the anaplastic lymphoma kinase (ALK) inhibitor crizotinib,» said lead author Professor Giorgio Scagliotti, head of the Department of Oncology, University of Turin, Italy.

On the contrary, p21 deficiency delays the onset of radiation - induced T - cell lymphomas, which is in line with the delay in the appearance of spontaneous T - cell lymphomas produced by p21 deficiency in ATM - null mice (32).

The outcome of peripheral T - cell lymphoma patients failing first line therapy: a report from the prospective, international T - Cell projcell lymphoma patients failing first line therapy: a report from the prospective, international T - Cell projCell project.

ONC201 demonstrated (GI50 1 - 8 µM) dose - and time - dependent efficacy in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), diffuse large B - cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt's lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T - cell lymphoma (CTCL), Hodgkin's lymphoma (nodular sclerosis) and multiple myeloma (MM) cell lines including cells resistant to standard of care (dexamethasone in MM) and primary samples.

Furthermore, in animal studies, changes associated with retareded tumorgenesis, such as decreased cell proliferation rates in various cell lines and decreased incidence of lymphoma, have been observed.

These cell lines will provide a tool to study the disease on a cellular level and determine the molecular behavior of lymphoma.

Cancers can be divided into three general groups: carcinomas that arise from epithelial cells that cover the body (skin) or line internal body surfaces; sarcomas that begin in connective, skeletal, muscular, or reproductive tissues; lymphomas that invade the lymph nodes and the lymphatic system.