Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and
lymphoma patients after bone marrow or hematopoietic stem cell transplants.
Not exact matches
In clinical trials the treatment — which involves extracting individual
patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive
lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in
patients six months
after treatment.
A team led by Øystein Fluge and Olav Mella at the Haukeland University Hospital in Bergen, Norway, discovered by chance that rituximab might help people with CFS
after seeing symptoms ease in a
patient who had both
lymphoma and CFS (PLoS One, DOI: 10.1371 / journal.pone.0026358).
Experience with
lymphoma patients, who receive a transplant of their own blood or bone cells
after radiation to wipe out their cancer, has shown «there's no doubt it helps,» says bone marrow transplant expert Nelson Chao of Duke University in Durham, North Carolina.
Scientists in Germany have developed a new approach that may prevent leukemia and
lymphoma patients from developing graft - versus - host disease (GvHD)
after therapeutic bone marrow transplants.
Their team discovered by accident that rituximab might work against CFS
after seeing symptoms ease in a
patient who had both
lymphoma and CFS.
The therapy is approved by the U.S. Food and Drug Administration for relapsed or treatment - resistant Hodgkin
lymphoma, and it is commonly prescribed to
patients whose disease has progressed
after autologous stem cell transplant, a procedure that replenishes the bone marrow with the
patient's own healthy stem cells
after therapy.
The FDA granted accelerated approval to nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for
patients with classical Hodgkin
lymphoma (cHL) whose disease has relapsed or progressed
after stem cell transplantation and the targeted antibody brentuximab vedotin (Adcetris).
The FDA granted approval to Yescarta ™ (axicabtagene ciloleucel, Kite / Gilead) for the treatment of adult
patients with several types of non-Hogdkin large B cell
lymphoma that is refractory or has relapsed
after at least two previous systemic treatments.
Scope: 22 institutions Treatment: CD19 - targeting CAR T - cell therapy Results: 42 % of
patients with aggressive large B - cell
lymphoma remained in remission
after 15 months
Brentuximab vedotin was previously approved by the FDA to treat cHL
after relapse, cHL
after stem cell transplant when a
patient is at a high risk of relapse or progression, systemic anaplastic large cell
lymphoma (ALCL)
after failure of other treatment, and primary cutaneous ALCL
after failure of other treatment.
As many as 30 percent of
patients who survive childhood Hodgkin
lymphoma develop a secondary cancer
after diagnosis, primarily breast cancer, non-Hodgkin
lymphoma, thyroid cancer or acute leukemia.
CAR T - cell Therapy: Scott McIntyre's Story
After many treatments for his B - cell
lymphoma failed, Scott McIntyre became the first UChicago Medicine
patient to undergo CAR T - cell gene therapy in a clinical trial.
The US Food and Drug Administration (FDA) has granted Priority Review designation for tisagenlecleucel (Kymriah), formerly known as CTL019, for treatment of adult
patients with relapsed or refractory diffuse large B - cell
lymphoma (DLBCL) who are ineligible for, or have relapsed
after, autologous stem cell transplant.
The US FDA has granted Priority Review designation for tisagenlecleucel (Kymriah) for treatment of adult
patients with relapsed or refractory diffuse large B - cell
lymphoma who are ineligible for, or have relapsed
after, ASCT.
Ibrutinib is also approved to treat chronic lymphocytic leukemia / small lymphocytic
lymphoma, including
patients with 17p deletion, mantle cell
lymphoma after at least one prior therapy, and
patients with Waldenstrom macroglobulinemia.
Dr. Diefenbach initiated the trial
after her research revealed that immune dysfunction in
patients with Hodgkin
lymphoma could indicate that some standard treatments were less likely to work.
Positron emission tomography (PET) imaging of metabolic tumor burden at diagnosis and
after induction therapy can help identify
patients most at risk of follicular
lymphoma (FL) recurrence, but more work is needed to differentiate high - risk and moderate - risk
patients, suggested findings from a pooled analysis of data from three prospective clinical trials, published in Blood.
Patients with Crohn's disease, psoriasis, rheumatoid arthritis, B cell
lymphoma and chronic lymphocytic leukemia have also developed the devastating brain disease
after immunosuppressant therapy with natalizumab and other drugs.
July 25, 2011 Two genetic variations predict second cancers
after radiation treatment for children with Hodgkin
lymphoma A genome - wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which
patients with Hodgkin's
lymphoma are most likely to develop radiation - induced second cancers years
after treatment.
Should all
patients with Hodgkin
lymphoma who relapse
after autologous SCT be considered for allogeneic SCT?
Hodgkin
lymphoma is typically considered to be more treatable, and more than 90 % of
patient survive more than five years
after their diagnosis.
Thirty - six percent of over 100 very ill
lymphoma patients appeared disease - free six months
after a single treatment, according to results released by the treatment's maker, Kite Pharma of Santa Monica, Calif..