In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to latent HCMV by employing other cellular proteins called
lysine demethylases to reactivate the virus.
The research team learned the virus brings with it to the cell a protein called UL138 that blocks the cellular
lysine demethylases from turning the virus back on.
KDM4A
lysine demethylase induces site - specific copy gain and rereplication of regions amplified in tumors.
Not exact matches
This, says Shi, drove home that the enzyme, dubbed
lysine - specific
demethylase 1 (LSD1), represses specific genes by maintaining unmethylated histones.
Researchers have now shown that an epigenetic enzyme called
lysine specific
demethylase 1 (Lsd1) plays a major part in this transformation.