Sentences with phrase «lysine residues of»

Mammal sirtuins are NAD + - dependent deacetylases that use NAD + as cofactor for catalyzed reactions to cleave acetyl groups from acetylated lysine residues of target proteins, generating nicotinamide (NAM) and 2 ′ - O - acetyl - ADP - ribose.

Not exact matches

Another important histone modification is acetylation (ac), which is the addition of an acetyl group to a lysine residue.

The simplest structure of glucosepane is a lysine residue linked to a arginine residue by a degraded form of glucose (which has turned into the imadazolium ring, etc).

They next undertook targeted sequencing of the lysine - 27 residue in all 16 genes that code for H3 isoforms in a validation cohort comprising 43 DIPGs and 36 non-brainstem glioblastomas.

Substrate peptides used in this assay were: the first 25 residues of histone 3 [H3 (1 - 25)-RSB- for G9a, EHMT1 and SETD7 at 10, 20 and 100 µM respectively; the first 24 residues of histone 4 [H4 (1 - 24)-RSB- at 10 and 500 µM for PRMT3 and SETD8 respectively; and H3K9Me1 [H3 (1 - 15), monomethylated at lysine 9] at 200 µM for SUV39H2.

This occurrence could have hindered the detection of junction - spanning peptides, since most mass spectrometry experiments involve digesting proteins with the enzyme trypsin, which cuts peptide chains exclusively after arginine and lysine residues.

HMT family of proteins consist of enzymes that methylate lysine or arginine residues on histone tails as well as other proteins.

He introduced a number of important techniques in chemical modification of proteins, in particular based on reversible amidination and trifluoroacetylation of lysine residues.

Biotin, an essential water - soluble B vitamin, has been known to modify tails of histone H2A, H3, and H4 through a covalent attachment of biotin to specific lysine residues catalyzed by the enzymes biotinidase and holocarboxylase synthase.»