Increased
lysosomal activity has been demonstrated in response to short - term fasting in transgenic mice expressing the autophagy gene, microtubule - associated protein 1A / 1B - light chain 3, fused with green fluorescent protein (38).
Not exact matches
Specifically, the current study demonstrated that an accumulation of oxidized dopamine depressed the
activity of
lysosomal glucocerebrosidase (GCase), an enzyme implicated in PD.
However, no connection has yet been made between the
lysosomal amino acid transporters and increased mTOR
activity in tumour cells.
However, data from other animal models demonstrate diminished
lysosomal enzyme
activity during extended periods of energy restriction (39).