Sentences with phrase «lysosomal degradation»
Lysosomal degradation refers to the process in our cells where lysosomes (a special part of our cells) break down and recycle or get rid of unwanted or damaged molecules, such as old proteins and cell parts. It helps to clean up the cells and maintain their proper functioning. Full definition
The molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways remain incompletely understood.
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D'Oro, U., Vacchio, M.S., Weissman, A.M. & Ashwell, J.D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.
However, Beclin 2, but not Beclin 1, functions in an additional lysosomal degradation pathway.
Rapid and reversible knockdown of endogenous proteins by peptide - directed lysosomal degradation.
The disrupted lysosomal degradation and resulting storage of HS and glycolipids such as gangliosides leads to severe neurodegeneration.
When an LDL particle (carrying cholesterol) binds to the LDLR, the particle is trafficked into the hepatocyte, and PCSK9 targets the receptor for lysosomal degradation.
Wnt proteins, regulators of development in many organisms, bind to seven transmembrane — spanning (7TMS) receptors called frizzleds, thereby recruiting the cytoplasmic molecule dishevelled (Dvl) to the plasma membrane.Frizzled - mediated endocytosis of Wg (a Drosophila Wnt protein) and lysosomal degradation may regulate the formation of morphogen gradients.
CXCR4 may then be recycled to the cell surface or ubiquitinated by AIP4 that results in the lysosomal degradation of CXCR4.
Currently, the drugs targeting autophagy initiation, membrane nucleation, and lysosomal degradation are under experimental or clinical investigation.