Sentences with phrase «lysosomal function in»

Elizabeth B. Moloney, PhD, is a post-doctoral research fellow at the Neuroregeneration Research Institute at McLean Hospital, where she is involved in developing both in vitro and in vivo approaches for understanding the role of lysosomal function in the pathophysiology of cellular aging and...

Not exact matches

That depression in turn weakened overall lysosomal function and contributed to degeneration of neurons.

The researchers found that degenerative changes and loss of vision are caused by impaired function of the lysosomal clean - up mechanism, or autophagy, in the fundus of the eye.

SPE - 39 family proteins interact with the HOPS complex and function in lysosomal delivery.

Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.

Both MPS IIIA and GM1 are classified as neuropathic (i.e. affecting the central nervous system) Lysosomal Storage Disorders, a group of approximately 50 rare inherited metabolic disorders that result from defects in lysosomal Lysosomal Storage Disorders, a group of approximately 50 rare inherited metabolic disorders that result from defects in lysosomal lysosomal function.

Although these lysosomal therapies are being tested in early - stage clinical trials, they inhibit other lysosomal functions beyond autophagy, and therefore may have additional side effects.

They suggest that the effects on lysosomes are secondary to reduced Aβ accumulation, but I suspect the causation may work in the reverse direction, since they found that HBCD lowered cellular membrane cholesterol, and abnormally high lysosomal membrane cholesterol can impair the acidification and function of lysosomes, which are necessary for clearance of intracellular Aβ.

The mucopolysaccharides, which aid in bone formation, as well as that of the skin, cornea and cartilage, don't perform their function properly because of a lack of lysosomal enzymes.