Sentences with word «lysosome»

A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.

Not only did APP accumulate in lysosomes of mice lacking NEU1 but researchers found evidence that the build - up promoted the production of Aβ - 42 and other toxic peptides tied to Alzheimer's disease.

Autophagosome sequesters the degradative targets, whose process is followed by fusion with lysosomes for degradation of its contents.

All of this damage damages extremely precious mitochondrial DNA, which make the mitochondrias dysfunctional, clogging lysosome for mitophagy, and being incapable of keeping mitochondrial membrane potential (leading to Cytochrome C loss through mitochondrial permeability pores) and mitochondrial ATP OXPHOS respiration.

When autophagy occurs, a bunch of little guys called lysosomes go around gobbling up damaged cells, damaged mitochondria, and cancerous cells.

Within the cell, the mineralized viruses enter into lysosomes, whose slightly acidic environment dissolves the mineral shell and releases the viruses.

The finding suggests a model in which mTORC1, located at the surface of cellular components known as lysosomes, receives «go / no - go» signals from a family of enzymes dubbed Rag GTPases.

The researchers looked at four proteins in blood exosomes that come from lysosomes.

Because these cells don't contain lysosomes, destruction had to occur by the other pathway.

Although stutterers that carry these mutations show no signs of mucolipidosis or other lysosome diseases, Drayna speculates that those drugs could be a useful therapy.

They were born without a working copy of CLN2, a gene whose protein helps lysosomes — the cell's garbage - disposing structures — break down a waste product called lipofuscin.

Taken together, this suggests that SRP - 6 protects worm cells against lysosome rupture and necrosis, the scientists conclude in the 21 September issue of Cell.

Osmotic release of β - glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3», 5» - monophosphate, and accelerated by cholinergic agents and guanosine 3», 5» - monophosphate.

By using video microscopy with fluorescent tagging of the two organelles, the scientists observed that the mitochondria and lysosomes formed stable contacts inside living human cells.

Identification of mechanisms regulating lysosome homeostasis and their role in protecting neurons against aging

Even my mother said I had to leave lysosomes.

STxB was taken up rapidly by live Gb3 - positive gastric cancer cells, following the intracellular retrograde transport route, avoiding lysosomes and rapidly reaching the Golgi apparatus and the endoplasmic reticulum.

These bags fuse with other bags, enzyme - rich lysosomes, which are filled with acids that degrade the contents of the vacuoles.

Large pale yellow spots are fat droplets, smaller ones waste - digesting lysosomes.

In follow - up studies, the scientists are now investigating how dysfunction of the proteins that tether mitochondria and lysosomes together may affect the function of the organelles, as mutations in some of these proteins have already been implicated in neurological diseases.

«The discovery of these mitochondria - lysosome contacts is extremely exciting,» said first author Yvette Wong, a postdoctoral fellow in Krainc's laboratory.

To their knowledge, this is the first time lysosomes have been implicated in a cell's division decisions.

Lysosomes act as a sort of recycling and disposal center for cells.

Insights obtained through these strategies are expected to answer fundamental cell biological questions about how cells match lysosome abundance and activity to demand.

To address these questions we perform high - throughput siRNA screening to identify new genes and mechanisms controlling lysosomal homeostasis, live cell imaging to observe lysosomes and the dynamic recruitment of proteins to them and biochemical approaches to define the molecular basis for such observations.

Indeed, mutations in multiple lysosomal genes result in severe neurodegeneration and it is becoming more clear that lysosomes also play a neuroprotective role in more common neurodegenerative diseases such as Alzheimer's disease that have not traditionally been associated with lysosomal defects.

The selected S. aureus antibody was then linked to a highly potent antibiotic that would be activated by and could function within the acidic environment of a phagocytic lysosome but could not function extracellularly.

I am sure that it can't be good for acidic lysosomes to be exocytosed in many other situations either.

Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.

So he took me for a summer and I learned to isolate lysosomes from cells using his method and looked at if the two systems we were studying were the same.»

After Cuervo completed her thesis, «there was a general agreement that I should forget about lysosomes,» she says.

Lysosomes just got interesting!

Does anyone know if lysosomes have ever been injected outside of cells to see if they would catch and kill viruses like the flu virus?

When we fast, we stimulate autophagy, which means that lysosomes gobble up these damaged mitochondria.

In the lipid storage form of lysosomal storage disease I mentioned that dogs and cats can be born with decreased or missing lysosome enzymes that allows them to process fatty substances (lipids).

One type of autophagy traps chunks of cellular material into «bags» that fuse with lysosomes.