Sentences with phrase «mab binding»

Not exact matches

One approach to tackle this challenge is to program into the therapeutic antibodies the capability of binding to receptors that can help the MAbs to cross into the brain.

The researchers found that with very few CDR mutations, or even none at all, VH1 - 46 mAbs could bind with the Dsg3 protein.

(A and B) Pandemic H1N1 reactive mAbs isolated from infected patients (1000, EM, 70, 1009) were assayed for binding to annual H1N1 influenza strain whole virus.

This mAb recognizes a discontinuous epitope on gp 120 and its binding depends on the tertiary protein structure and intact carbohydrates (1).

This protein binds to human T - cell receptor CD4 in ELISA and Western ELISA as determined by CD4 / gp120 / Anti gp120 mAb - peroxidase capture ELISA.

mAb 246 - D binds to overlapping hexapeptides which identified its core epitope as qqLLGIwg (aa 591 - 598) which is located in the immunodominant region (cluster I) of gp41, just upstream from

c) As b) but bind sCD4 and confirmation dependant Mabs.

Do not bind sCD4 or IIIB mabs recognising conformation dependant epitopes.

Four of the mAbs, 2T5C9, 2G9C, T1F11, and TB2H7, demonstrated diagnostic potential in enzyme - linked immunosorbent assays (ELISA) by their low to sub-nanomolar cross-reactivity with recombinant wild - type (WT) and mutant TTR aggregates and lack of binding to native TTR or amyloid fibrils formed by other peptides or proteins.

However, mAbs had lower maximum binding signals, indicating that pAbs were required to saturate a diverse collection of binding sites.

An unconventional (non-CDR) component to pAb's activity was indicated from control human mAbs, generated against non-amyloid targets, binding to aggregated Aβ and TTR.

Methods: A novel human mAb, IRAB - A, was identified by phage screening using competition binding and surface plasmon resonance assays with the IR extracellular domain.

The Fab fragment of mAb 5.91, pre-incubated with canine IgE, reduced the binding of canine IgE to the monocyte cell population from 15 % to 5.6 %.

Moreover, the intact mAb 5.91 was able to bind the free IgE to prevent it from binding cell surface receptors.

This demonstrated that the Fab fragment of mAb 5.91 was even more effective in reducing the binding of IgE to the monocyte cell population than the intact mAb 5.91.

Results showed that the whole mAb 5.91 molecule reduced the amount of binding of canine IgE to the monocyte cell population from 15 % to 7.7 %.