Sentences with phrase «mtor signalling pathways»

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

When the mitochondrial translation rate increases, the mTOR signaling pathway is activated, which causes the increase in the cytoplasmic protein translation rate to counteract pressure from the increased mitochondrial translation, thus representing a new evolutionary adaptation mechanism.

In order to keep step with the «quickened» mitochondrial translation, somatic cells activated the mTOR signaling pathway in order to accelerate cytoplasmic translation and balance mitochondrial translation.

Click to see a schematic of the mTOR signaling pathway.

Cisplatin regulates cell autophagy in endometrial cancer cells via the PI3K / AKT / mTOR signalling pathway.

The PI3K / Akt / mTOR signaling pathway is critical in the immune response of T cells.

The Akt / mTOR signaling pathway has a critical role in CD4 + T cell differentiation and function.

Pterostilbene limits the expression of the mTOR signaling pathway, which helps to regulate the growth, survival and proliferation of cells.

Suppressing the mTOR signaling pathway has been shown in animal studies to extend lifespan — in fact, scientists say that inhibiting the pathway by 25 percent can translate to a 20 percent increase in lifespan.

BetaTOR has been shown to increase the phosphorylation of mTOR, thus activating the mTOR signaling pathway in muscle.

For example, because long - term use of marijuana downregulates the expression and responsiveness of the CB1 receptor, in a manner similar to frequent blood sugar swings leading to insulin resistance, some say that THC may impair muscle building by interrupting the mTOR signaling pathway, which is important for protein synthesis.

Not exact matches

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K / AKT / mTOR, upon which the leukemia cells have become dependent.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

Furthermore, niclosamide showed significant antitumor activity against a panel of cervical cancer cell lines via inhibition of mitochondrial respiration and the mammalian target of rapamycin (mTOR) signaling pathway [42].

The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.

We are particularly interested in the calcineurin - NFAT pathway and mTOR pathway in immune signaling.

Inhibition of the PI3K / AKT pathway down - regulates mTOR signaling proteins.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

[42 - 46] KIT, a type III transmembrane receptor tyrosine kinase that sits upstream of NRAS and BRAF, feeds into several signaling pathways, including both the RAS / RAF / MEK / ERK cascade and the PI3K / Akt / mTOR pathway.

At the cellular level, p53 can either induce senescence or, of major interest here, inhibit senescence by controlling both reactive oxygen species (ROS) levels and a signaling pathway mediated by protein kinases AMPK and mammalian target of rapamycin (mTOR).

Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC - J2) through PI3K / Akt / mTOR and ERK signaling pathways

The Buck's Kennedy is conducting research on cell - signaling pathways, in particular the mTOR pathway, which senses cellular nutrients, oxygen and energy levels and tells cells whether to grow, divide or stop.

Due to reduced mTOR activity, a key intracellular signaling pathway regulator, the function of the cell's power plants, the mitochondria, is disrupted.

The augmented anabolic response to amino acids and insulin was shown to be due to an increased activation of the mTOR / p70S6K signalling pathway, which is considered an integral control point for muscle protein anabolism and muscle cell growth.

Eating too much protein can also activate your body's most important signaling pathway — mTOR, or the mammalian target of rapamycin — and boost your risk of cancer.

Insulin and leptin receptor resistance from too many net carbs and activation of the mTOR metabolic signaling pathway by too much protein.

\ u003cbr \ u003e \ u003cbr \ u003e \ u003cstrong \ u003eGaspari Nutrition SizeOn ¨ Max Performance Benefits: \ u003c\ / strong \ u003e \ u003c\ / p \ u003e \ n \ u003cul \ u003e \ n \ u003cli \ u003eSpeeds up Protein Synthesis \ u0026amp; Muscle Force Recovery \ u003c\ / li \ u003e \ n \ u003cli \ u003eHeightened Muscle Volume, Muscle Fiber Size, Cell Volume \ u0026amp; Plasma Amino Acid Levels \ u003c\ / li \ u003e \ n \ u003cli \ u003eIntensifies S6K1 and 4E - BP1 Signaling and Hypertrophic mTOR Pathway Conduction \ u003c\ / li \ u003e \ n \ u003cli \ u003eInitiates \ u0026amp; Maintains Myogenesis and Muscle Recovery While You Are Still Training \ u003c\ / li \ u003e \ n \ u003cli \ u003eTransports Vital Nutrients, Essential Minerals, and Growth Co-factors To Skeletal Muscle Tissue.

Leucine is the catalyst in signaling the mTOR pathway which activates protein synthesis.

Reactive oxygen species (ROS) are not universally bad, and one of their important functions is to signal the body to increase protein synthesis as part of the mTOR pathway.

Amino acid signals and growth factor / insulin signals are thought to converge on the mTOR pathway — sometimes called the master regulator of nutrient signalling.

The full pathway is in an earlier comment here, while this is an abbreviated diagram of where leucine interacts wiith insulin / IGF -1 / mTOR signalling (mTORC1 is the mTOR complex associated with growth signalling):

Diindolylmethane transduces signaling via aryl hydrocarbon (Ah) receptor, NF - κB / Wnt / Akt / mTOR pathways, to help inhibit growth.

Insulin signalling molecules (including IGF - 1, IGF - 1R and C - Peptide) and pathways (akt / mTOR and Ras / MAPK) have all been linked to increase cancer risk and promotes the development of cancer cells (8).