Sentences with word «macrocyclic»

Discontinue the use of macrocyclic lactones as a «slow kill» protocol for known heartworm infections; it is NOT recommended by the American Heartworm Society.

Unfortunately, the use of macrocyclic lactones for generalized demodicosis is considered extralabel, and there is no antidote to the potentially serious and life - threatening side effects.

Macrocyclic GBCAs were originally developed as a safer alternative to linear GBCAs.

Macrocyclic peptides have sparked pharmaceutical industry interest, because they have certain physical and chemical properties that could become the basis of a new generation of medications.

Citing the need to better understand critical issues such as macrocyclic lactone resistance to heartworm preventives and the role of the immune system in heartworm prevention, the American Heartworm Society (AHS) has announced that it is accepting proposals for new heartworm research studies.

Originally from the UK, Faust travelled to New Zealand to deliver a presentation at the International Symposium on Macrocyclic and Supramolecular Chemistry on an Engineering and Physical Science Research Council award — a prize for top - performing PhD students.

The chief drawback in using ivermectin and other macrocyclic lactones is that a few dogs are highly sensitive to them.

Some dermatologists will have the owner sign a consent - to - treat form outlining this information before macrocyclic lactones use.

i. Administer an approved macrocyclic lactone product.

Unlike dogs, heartworm - positive cats are at very low risk of developing adverse reactions from macrocyclic lactones.

The major class of preventatives include macrocyclic lactones, including ivermectin, milbemycin, moxidectin, and selamectin).

TAMLs: There's no pretty way to say it — TAML is short for tetra - amido macrocyclic ligand — but these apparently harmless chemicals break down a variety of stubborn pollutants, including pesticides, dyes and industrial runoff.

For example, cyclotetradecanone and cyclohexadecanone, two other macrocyclic ketones, would respectively exit the GC column used in these experiments approximately 3 minutes before and after cyclopentadecanone.

The RealTime Lab mycotoxin test detects 15 different mycotoxins, including 9 macrocyclic trichothecenes.

[Several] products contain macrocyclic lactones which kill the tissue stages of heartworm larvae and are given once a month.

a. Administer macrocyclic lactone preventive drugs to dogs greater than 6 weeks of age prior to relocation.1

The new text on the CAPC website states: «Recent work has shown that there are isolates of heartworms that are capable of developing to adults in dogs receiving routine prophylaxis with any of the available macrocyclic lactones.»

The medications used to prevent heartworm infection in your pet belong to a class called avermectins (Macrocyclic Lactones).

To answer those questions I'll focus on a popular commercial macrocyclic lactone called ivermectin.

The «slow kill» therapy sometimes prescribed by veterinarians is never appropriate, as it has been demonstrated that using this modality — repeated macrocyclic lactone administration over a period of time — increases the proportion of circulating microfilariae that possess resistance markers.

Any method utilizing only macrocyclic lactones as a slow - kill adulticide is not recommended.»

Use microfilaricidal doses of macrocyclic lactones to reduce transmission from pets receiving adulticidal treatment.

Also, dogs should have negative heartworm disease test results before macrocyclic lactone therapy is implemented.

A single dose of topical moxidectin prior to transport will eliminate most microfilariae.4 - 6 OR Administer an approved macrocyclic lactone product along with a topical canine insecticide (containing permethrin + dinotefuran + pyriproxyfen) that is labelled to kill and repel mosquitoes.

In recent years veterinarians have made greater use of a group of chemicals known as macrocyclic lactones.

When using macrocyclic lactones for generalized demodicosis, the owner must understand its extralabel use and potential for side effects.

Efficacy of macrocyclic lactones decreases below 100 % in dogs, however, if first administered > 2 months after exposure to infective larvae.

But no MRI abnormalities appeared in the brains of rats injected with the macrocyclic agent, gadoterate meglumine.

Another group of animals were injected with a different type of GBCA — the «macrocyclic» agent gadoterate meglumine.

«Certain of these agents lead to heavy - metal deposition in parts of the brain, which is not seen with the macrocyclic GBCAs,» says Dr. Runge.

Since the patients in the study received only the linear type, additional research is needed to see if the macrocyclic type can prevent MRI hyperintensity, according to Dr. Kanda.

There are two types of Gd - CM, linear and macrocyclic, with distinct chemical compositions.

An example of a macrocyclic peptide drug success story is cyclosporine, an immunosuppressant for organ transplants and some autoimmune disorders.

The replacement of one of the two tetra - aza - macrocyclic rings with a pseudo diamine - segment, mimicking the first two amino groups of the lacking macrocyclic ring from the point of attachment at the benzylic position, was attempted since it was assumed that identical features for both rings were not required.

The unique structural feature of these compounds is the presence of a core structure, a substituted (R), (S) or (RS)(N «-(1H - benzimidazol -2-ylmethyl)- N «-5,6,7,8-tetrahydroquinolin-8-yl-1,4-alkylamine)(48) that replaces the macrocyclic nucleus of bicyclams.

Macrocyclic lactones.

Ivermectin and the macrocyclic lactones.

Macrocyclic lactones include the avermectins (ivermectin and doramectin) and milbemycins (milbemycin oxime and moxidectin).

Macrocyclic lactones do not readily cross the mature mammalian blood - brain barrier.17 Safety in mammals is due to the lack of glutamate-gated chloride channels in the peripheral nervous system and the restriction of GABA to the central nervous system.

If the label protocol proves to be ineffective, it may be more acceptable to use a macrocyclic lactone instead of extralabel amitraz.

Table 5: Macrocyclic Lactone Dosages for Generalized Demodicosis in Dogs The ease of oral administration compared with dips makes macrocyclic lactones the first line of therapy for many dermatologists (Table 5).

Selamectin, the active ingredient in Revolution, is a macrocyclic lactone compound.

But by that time, pharmaceutical companies will probably have other medications than macrocyclic lactones to prevent and treat heartworms.

More commonly, microfilariae are eventually eliminated, even from non-adulticide-treated dogs, after several months of treatment with prophylactic doses of the macrocyclic lactones.

The macrocyclic lactones are the safest and most effective microfilaricidal drugs available.

Until now, however, experts have been careful to avoid using the so - called R word, «resistant,» to describe the strains that appear not to respond as expected to macrocyclic lactones.