Sentences with word «macrophage»

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the activation of macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.

Previous studies have pointed to immune cells called macrophages as the primary immune cell responsible for engulfing and breaking down nerve debris.

The researchers took blood samples from Alzheimer's patients as well as healthy controls, then isolated important immune cells known as macrophages from the blood.

CD4 + T Cells Are as Protective as CD8 + T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity.

HIV Persistence in tissue macrophages of humanized mice during ART.

(E) Intracellular (internalized) and extracellular bacteria (cell - free culture media) were quantified at 1 h after ex vivo infection of alveolar macrophages with an MOI of 20.

Suspecting that the two events were related, Stromnes looked and discovered that the tumors were indeed attracting these Gr - MDSCs by releasing a protein called granulocyte macrophage colony - stimulating factor (GM - CSF).

Monocytes are a specific type of phagocytic cells which enter the damaged muscle fiber and transform into macrophages which also produce toxins which further destroy the damaged area.

Five years ago, researchers led by Dennis Discher, a cell biophysicist at the University of Pennsylvania, reported that in human cells CD47 binds to a receptor protein on macrophages called SIRPα.

Two - dimensional liquid chromatography - tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.

The researchers infected macrophages derived from 80 African and 95 European individuals with either Listeria monocytogenes or Salmonella typhimurium to look for differences in response and related them to ancestry.

As reported in the Journal of Acquired Immune Deficiency Syndromes, the researchers discovered that HIV - infected adolescent males had increased levels of sCD14 — a marker of macrophage activation.

Just as in pipes, they bind to the calcium in bones, where they're gobbled up by white blood cells called macrophages which eat up old bone cells so they can be replaced with new ones.

They'll be making comparisons between the microRNA profiles within macrophages isolated from human and dog osteosarcoma samples.

They show that highly purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4 antibody.

Asthma has been correlated with an overabundance of one type of immune cell called M2 macrophages in the lungs.

Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88 - dependent: role of the innate immune response in Celiac disease.

Cancer cells produce the enzyme nagalase which promotes viral infections and suppresses activated macrophage activity from destroying infected cells.

This finding suggests that high cellular cholesterol content could push immune cells like macrophages into tumor - fighting mode and presents a very intriguing paradox: namely that inflammation that is deadly in the context of atherosclerosis may be beneficial when it comes to cancer.

A loss of Vγ4 + Ccr6 + cells was also observed following CD169 + macrophage ablation using CD169 - DTR mice (Figure 7F).

Legionella pneumophila, the bacterial cause of Legionnaires» disease, lives symbiotically inside wild aquatic amoebas and similarly mistakenly infects human macrophages when victims inhale it.

The functions of the Salmonella - affected macrophage proteins were diverse, including production of antibacterial nitric oxide, production of prostaglandin H2, and regulation of intracellular traffic.

In preliminary studies, Madsen and Hirschberg demonstrated the feasibility of using macrophages as delivery vehicles for gold - based nanoparticles.

«When macrophages attack Pseudomonas to get rid of it, the bacterium turns around and shoots them,» Frank says.

In particular, we are interested in the contributions of the innate immune system, including the resident macrophage in the liver (Kupffer cells) and the complement pathway, in the initiation and progression of ethanol - induced liver injury.

Under similar conditions in vitro, a significant number of bacteria harbored within macrophages also survived treatment.

The resulting disease - causing (virulent) parasite forms, called amastigotes, infect and multiply in immune cells called macrophages at the bite site and after dissemination of the infection to secondary sites.

White adipose tissue messenger RNA levels and serum concentrations of inflammatory cytokines (tumor necrosis factor - α, interleukin - 6, and monocyte chemoattractant protein - 1) were reduced by C3G, as did macrophage infiltration in adipose tissue.

It also helps immune cells like macrophages function better, helping the body resist infection.

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting.

By giving mice antibiotics to kill off the bacteria, the communication between macrophages and neurons is interrupted resulting in decreased BMP2 and CSF1 production and disrupted intestinal contractions.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Ultimately, Godwin would like to understand why macrophages produced by adult mice and humans don't suppress scarring in the same way as in axolotls and then identify molecules and pathways that could be exploited for human therapies.

The researchers showed that this protein buildup inside macrophages results from problems with the waste - disposal functions of the cell.

In mice mimicking hPAP that lacked expression of the mouse gene — Csf2rb, the researchers used a viral vector to deliver a correct version of Csf2rb to abnormal alveolar macrophages taken from the animals.

The study, «Aging in mice is associated with p16 (Ink4a)- and beta - galactosidase - positive macrophage accumulation that can be induced in young mice by secreted factors of senescent cells,» will be published in print in the July issue of Aging.

«Myeloid cells including macrophages have receptors for stress signaling molecules, which allows them to respond to cues from the sympathetic nervous system,» explains Hanna.