Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA - induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal
macrophage activation in mice.
Not exact matches
«We hope that interventions to decrease
macrophage activation early
in HIV infection will decrease associated bone loss, which has become a major adverse side effect of HIV infection and its treatment,» Aldrovandi said.
«HIV - infected young males have higher rates of bone loss than females: Study suggests
macrophage activation as possible reason for differential bone loss
in adolescent males.»
An early - stage clinical study by another institution, published
in the Lancet Oncology
in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and
macrophages whose
activation stimulates these cells to infiltrate tumors.
«These findings question a long - held paradigm that myelin - specific T cells initiate inflammation
in the brain through
activation of microglia and brain
macrophages,» says Scott Zamvil, MD, PhD, a professor of neurology at the University of California, San Francisco and co-author on the paper.
What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the
activation of
macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.
This
activation causes additional stress which keeps the
macrophages «turned on»
in a cycle that amplifies and further damages the cells and surrounding tissues.
Through studies conducted
in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf,
in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens
activation of tissue - destructive immune cells called
macrophages.
A balance between the
activation of the inflammatory
macrophages and suppression of the anti-inflammatory
macrophages in the kidney may play a pivotal role
in kidney stone formation.
According to Faron, the Clevegen antibody is well differentiated from competing products by its ability to specifically target TAMs of the M2 variety (which facilitate tumor growth) while sparing M1
macrophages that support antitumor immune
activation and desirable immunity
in general.
1,25 - dihydroxyvitamin D3 protects against
macrophage - induced
activation of NF?B and MAPK signalling and chemokine release
in human adipocytes.
Activation of a TGF --LCB- beta -RCB-- Specific Multistep Gene Expression Program
in Mature
Macrophages Requires Glucocorticoid - Mediated Surface Expression of TGF --LCB- beta -RCB- Receptor II.
Pathways regulating cytosolic phospholipase A2
activation and eicosanoid production
in macrophages by Candida albicans.
Anna Huttenlocher, University of Wisconsin, USA Neutrophils
in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality
in pulmonary tuberculosis Constitutive BAK
activation as a determinant of drug sensitivity
in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of
macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment i
macrophage metabolism directs immune cell polarization
in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through
Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment i
Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment
in disease?
Activation of cytosolic phospholipase A2α
in resident peritoneal
macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.
The supernatant of apoptotic cells causes transcriptional
activation of hypoxia - inducible factor — 1α
in macrophages via sphingosine -1-phosphate and transforming growth factor - β.
It is a potent cytokine
in the development, further
activation and trafficking of
macrophages, DCs and other innate cells.
Without Nr4a1 to put a damper on production, monocytes and
macrophages increase secretion of norepinephrine, which
in turn leads to the
activation of
macrophages, thereby amplifying neuroinflammation and causing a massive influx of T cells into the central nervous system.
Heart regeneration
in the salamander relies on
macrophage - mediated control of fibroblast
activation and the extracellular landscape, npj Regenerative Medicine (2017).
Scientists aren't exactly sure, but
in line with the study on NF - KappaB, they believe that glycine acts directly on inflammatory cells such as
macrophages to suppress
activation of transcription factors and the formation of inflammatory cytokines
in the first place.
Similar to a pathogenic response to an invading bacterium, excess nutrients found
in the obese adipose microenvironment can lead to the pro-inflammatory
activation and phenotypic switch (from M2 resident to M1 inflammatory
macrophage) of
macrophage [24].
Ghosh SS, Bie J, Wang J, Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet - induced atherosclerosis and glucose intolerance
in LDLR - / - mice — role of intestinal permeability and
macrophage activation.
Rheinanthrone, a metabolite of sennoside A, triggers
macrophage activation to decrease aquaporin - 3 expression
in the colon, causing the laxative effect of rhubarb extract.
Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet - induced atherosclerosis and glucose intolerance
in LDLR - / - mice — role of intestinal permeability and
macrophage activation.