Sentences with phrase «macrophage populations»

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

Steve Gerondakis and colleagues establish that Rel (from the c - rel gene) in mice is a positive or negative regulator of transcription in macrophages and that Rel has distinct roles in different macrophage populations.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

Separately, the high levels of a type of T cell called Th17 cells secrete gobs of interleukin - 17 (IL - 17), expanding macrophage populations.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

«I think the key is the immune system needs to be balanced,» says Dhandapani, noting the seesaw effect on the macrophage population that happens following injury.

Not exact matches

We also discovered that when we depleted neutrophils, nerve debris clearance was significantly halted in both normal mice and mice lacking a major population of macrophages.»

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response.

Among the three isolated cell populations, the relative gene expression of macrophage markers was highest among the F4 / 80 + cells.

The adipocyte - enriched population (gray bars) expressed small amounts of the macrophage markers (a), consistent with residual macrophage contamination seen by immunofluorescent staining of live cells (b).

Expression analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue showed that adipose tissue macrophages are the primary sources of TNF - α and other proinflammatory molecules in adipose tissue.

Of the three adipose tissue cell populations, the F4 / 80 + adipose tissue macrophages were the predominant source of TNF - α expression.

Nos2 was expressed by both macrophages and F4 / 80 — SVCs, and Il6 was detectably expressed by all three populations in adipose tissue.

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

Intriguingly, these cells, which resemble perivascular macrophages or so - called «Mato Cells» in mammals, appear to emerge by transdifferentiation from endothelium of the optic choroidal vascular plexus, and as such would represent the first described perivascular cell population in the brain derived from vascular endothelium.

This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.