Not exact matches
We also discovered that when we depleted neutrophils, nerve debris clearance was significantly halted
in both normal mice and mice lacking a major
population of
macrophages.»
In this study, the researchers found that a specific
population of immune cells called
macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.
Different clonal memory cell
populations had different B cell or
macrophage helper compositions that matched effector cell
populations generated much earlier
in the response.
Trapnell and Suzuki were prompted to test the novel
macrophage transplantation therapy by studies showing that resident
macrophage populations (such as those residing
in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.
Expression analysis of
macrophage and nonmacrophage cell
populations isolated from adipose tissue showed that adipose tissue
macrophages are the primary sources of TNF - α and other proinflammatory molecules
in adipose tissue.
Nos2 was expressed by both
macrophages and F4 / 80 — SVCs, and Il6 was detectably expressed by all three
populations in adipose tissue.
To determine whether adipose tissue
macrophages express any molecules implicated
in obesity - associated complications, we isolated three cell
populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched
population, (b) a stromal vascular
macrophage F4 / 80 +
population, and (c) an F4 / 80 — stromal vascular
population.
Steve Gerondakis and colleagues establish that Rel (from the c - rel gene)
in mice is a positive or negative regulator of transcription
in macrophages and that Rel has distinct roles
in different
macrophage populations.
The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of
macrophage gene expression: distinct roles for Rel
in different
macrophage populations.
Intriguingly, these cells, which resemble perivascular
macrophages or so - called «Mato Cells»
in mammals, appear to emerge by transdifferentiation from endothelium of the optic choroidal vascular plexus, and as such would represent the first described perivascular cell
population in the brain derived from vascular endothelium.
This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion
in the absence of this
population had nothing to do with deregulated
macrophage activity.