Sentences with phrase «macrophages also»

The recent study was a follow - up to an earlier study which found that macrophages also play a critical role in limb regeneration.

, a significant number of bacteria harbored within macrophages also survived treatment.

Under similar conditions in vitro, a significant number of bacteria harbored within macrophages also survived treatment.

Not exact matches

We also discovered that when we depleted neutrophils, nerve debris clearance was significantly halted in both normal mice and mice lacking a major population of macrophages.»

Researchers also found a type of immune cell (multinucleated macrophage giant cells) in the ovaries of reproductively «old» mice only.

The sex - specific differences — the smaller hippocampus, the presence of fewer nerve cells, the existence of immune system macrophages in places they shouldn't be — were also found in adulthood.

These findings also have implications for treatment of cancer and other disorders, such as obesity, in which M2 macrophage cells play a regulatory role in tumor growth and fat deposition.

There was also an enhancement of infiltrating CD8 + cells, macrophages and natural killer cells.

Analysis of the tumour showed that it also been infiltrated by macrophages.

Several of the viruses also release the gene for granulocyte - macrophage colony - stimulating factor (GM - CSF) an immune system protein.

On top of their positive effect on pathogens, macrophages can also play a negative role in cancer biology.

Under the supervision of Claudia Binder, MD / PhD, I also carry out research, examining the interactions of tumour cells and macrophages.

Furthermore, these results also have an important prognostic value — the positioning of macrophages in hypoxic tumor regions would be an indication of a poor prognosis, while the localization of macrophages in normoxic regions of the tumor could predict a better disease outcome.

Macrophages not only migrate to sites of infection and phagocytose pathogens, but also modulate immune system activity to ensure proper organ function and regeneration.

«Results also identified mechanisms regulating the numbers and phenotype of macrophages in the tiny air sacs of the lungs (called alveoli) in health and disease,» said Takuji Suzuki, MD, PhD, the study's first author and a scientist in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's.

According to Harkema, the DHA could be changing the way these cells, also known as macrophages, react to the silica in the lungs and somehow alter the immune system's response.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Copeland's team also noted that these mice suffered from a host of immune - related problems, the most crippling being a flood of macrophages — a type of white blood cell — damaging the lungs and other organs.

They also filled the tablet with GMC - SF (granulocyte macrophage colony - stimulating factor), an inflammatory protein known to attract immune cells.

These animals also had fewer macrophages in their livers as well as less fibrosis.

By searching the scientific literature, Munn found that the macrophages» tryptophan - eating enzyme, called IDO or indoleamine 2,3 - dioxygenase, was also produced in large quantities by human placental tissue.

Her research suggested that T cells can also send signals that activate the brain's resident immune cells, microglia and blood - borne macrophages, telling them to protect the injured neurons from toxins released by the injury.

They also injected various antibodies that bind to cancer cells, which help to activate macrophages that might enter the tumor.

The researchers were also able to detect SIV DNA and RNA in the combined total SVF as well as in isolated adipose tissue macrophages and CD4 + T cells.

This is a key finding that suggests disease onset outside of alveolar macrophages is not only possible, but also important in the pathogenesis of tuberculosis infection.»

«If the usefulness of these macrophage markers is established, it will be possible to evaluate kidney stone risk not only through inorganic but also some organic substances.

Resolvin also hastened the change of macrophages in the heart tissue from classic macrophages to reparative macrophages, which indicated an expedited healing response.

«In the past we have also shown that in mice, certain regulatory mechanisms protect against urinary calcium oxalate stone formation, and that these mechanisms may be mediated by anti-inflammatory Type 2 macrophages (M2s).

The resulting fragments attract several types of immune cells, which led pulmonologist Steven Shapiro of Washington University in St. Louis to suspect that the fragments might also attract more of the same kind of macrophages that started destroying elastin in the first place.

Preadipocytes may also have phagocytic capabilities similar to macrophages (53).

Our data also suggest that the increased accumulation of macrophages in adipose tissue of the obese is due to an influx of bone marrow — derived precursors into adipose tissue and their subsequent differentiation into mature F4 / 80 - expressing macrophages.

C. gattii not only can kill macrophages, they can also hide inside them.

Macrophage - deficient FVB / NJ Csf1op / op mice are also deficient in F4 / 80 + cells in adipose tissue.

Recently, several observations suggested that, besides monocyte - derived macrophages, dendritic cells, a distinct myeloid lineage, also express PPARγ at high levels.

During this process, the high levels of glucose and lipids also activate multiple forms of a molecule called protein kinase C (PKC), which help these unhelpful macrophages to activate, survive and multiply, thus boosting inflammation.

It was also reported that PPARγ is expressed in cells of monocyte origin such as macrophages and that it modulates the function of these cells.

The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.

They have also shown that, interestingly, itaconate has an anti-inflammatory effect when these macrophages are activated.

BTLA is also expressed by all mature lymphocytes, splenic macrophages, and mature, but not immature bone marrow - derived dendritic cells.

The researchers also identified a counteracting repressor protein in the cells that actively shut off macrophage - favoring genes during neutrophil differentiation.

Immune effector systems also consist largely of metazoan innovations, such as the macrophage - expressed gene 1 (MPEG1) that participates directly in pathogen elimination38.

Recent evidence indicates that macrophages are also key players in metabolic homoeostasis.

«Until now, we did not have a way to delete a gene only in monocytes without also deleting it in macrophages,» says Graham Thomas, Ph.D., a postdoc in the Hedrick lab and the study's first author.

Although macrophages, like dendritic cells, also take up antigens, they are more likely to degrade them than present them to T cells.

Her research may lead to improved diagnostic tools and also facilitate the development of novel cancer therapies that prevent tumor recruitment of macrophages and, as a result, impair a cancer's ability to metastasize.

A loss of Vγ4 + Ccr6 + cells was also observed following CD169 + macrophage ablation using CD169 - DTR mice (Figure 7F).

Neutrophils, eosinophils, and macrophages are also sources of cellular ROS.32

In addition, other inflammatory immune cells, known as macrophages, are also turned on within fat tissue.

2009 Direct and macrophage - mediated actions of fatty acids causing insulin resistance in muscle cells 2010 Muscle insulin resistance: assault by lipids, cytokines and local macrophages Fats, again especially long - chain saturated fats, are also implicated in the progressive loss of pancreatic β cells in type 2 diabetes.

It has long been known that antibiotics suppress various immune functions, and especially macrophage activities such as chemiluminescence response, chemotactic motility, bactericidal and cytostatic ability and similar negative effects have also been seen with other commonly used drugs such as H2 - blockers, proton inhibitors and surface - protection agents.