Sentences with phrase «macrophages in»

Takano T, Azuma N, Satoh M, Toda A, Hashida Y, Satoh R, Hohdatsu T. 2009 Neutrophil survival factors (TNF - alpha, GM - CSF, and G - CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions.

Activity of pulmonary intravascular macrophages in cats and dogs with and without adult Dirofilaria immitis.

Macrophage colony - stimulating factor (M - CSF) is reported to enhance a variety of functions of mature monocyte / macrophages in vitro.

They work by plugging into immune cells; more specifically, they connect to macrophages in the blood stream and macrophages «digest» these polysaccharides and redistribute them throughout the immune system so every other immune cells gets the benefits from them.

Canadian Society for Immunology (CSI) Symposium Dendritic Cells and Macrophages in Health and Disease: Remembering Cheolho Cheong Saturday, May 13, 8:00 AM — 10:00 AM, Room 202B Chairs: Clinton S. Robbins, Peter Munk Cardiac Ctr., Toronto Gen. Res.

The next step is to study the function of macrophages in salamanders and compare them with their human and mouse counterparts.

tuberculosis and cytotoxicity toward macrophages in a high throughput manner.

After confirming the role of the macrophages in the function of the digestive tract, the researchers looked for how the regulation happens.

So he tried to perform an MRI scan on the heart of a mouse that was genetically engineered to not have macrophages in their hearts.

Researchers from Penn State College of Medicine, in collaboration with other scientists, have reported the role of macrophages in regulating the contractions of the colon to push digested material through the digestive tract.

Nahrendorf was curious about those macrophages in the heart.

Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies.

How a mycobacterial lipid subverts host macrophages in tuberculosis and leprosy Lalita Ramakrishnan University of Cambridge, UK 20th October 201704:15 pm Host: Pedro Alves, MPIIB Location: Max Planck Institute for Infection Biology, Seminar room 1 +2 - Campus Charité Mitte

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN - γ in a nitric oxide - dependent manner.

Furthermore, the macrophages in the ARG+PRO group showed less cytokine stimulation and pro-inflammatory activity than the other groups.

Future studies could focus on boosting the response of liver and spleen macrophages in people with ongoing viral infections, Norbury said.

Adipose tissue macrophages in mice with varying degrees of adiposity.

In contrast, the macrophages in adipose tissue from obese animals were frequently found in aggregates.

In mice, both body mass and adipocyte size were strong predictors of the percentage of F4 / 80 + macrophages in the perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue depots.

The study showed that mice lacking the SNRK gene had a significantly higher concentration of macrophages in white fat tissue compared with normal mice.

Macrophages in the adipose tissue of lean mice were uniformly small, isolated, and widely dispersed among the adipocytes.

Rotavirus - specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissue.

Macrophages in the liver and muscle of lean and obese mice.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

The close relationship between adipocyte size and the abundance of macrophages in adipose tissue suggests that the influence of adipocyte size on adipocyte function may be conveyed through a paracrine pathway involving adipose tissue macrophages.

Our data also suggest that the increased accumulation of macrophages in adipose tissue of the obese is due to an influx of bone marrow — derived precursors into adipose tissue and their subsequent differentiation into mature F4 / 80 - expressing macrophages.

In a study published in Diabetes on February 6, researchers identified CST's role in the recruitment and function of macrophages in the liver as well as regulation of obesity - induced liver inflammation and insulin resistance.

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

The accumulation of adipose tissue macrophages in direct proportion to adipocyte size and body mass may explain the coordinated increase in expression of genes encoding macrophage markers observed in our microarray expression data.

When they put human macrophages in the lower compartment filled with cell culture medium, the cells rose toward the membrane.

There's evidence that immune cells called macrophages in belly fat become inflamed as we get older.

Resolvin also hastened the change of macrophages in the heart tissue from classic macrophages to reparative macrophages, which indicated an expedited healing response.

A balance between the activation of the inflammatory macrophages and suppression of the anti-inflammatory macrophages in the kidney may play a pivotal role in kidney stone formation.

«The protein Smurf1 functions in specialized white blood cells called macrophages in both mice and humans, thereby suggesting a conserved evolutionary pathway,» said Dr. Shiloh, co-senior author of the study along with Dr. Beth Levine, Director of the University's Center for Autophagy Research.

However, regulatory roles of M2 macrophages in urinary stone formation in humans have not been studied.»

The team headed by Thierry Soldati, Professor at the Biochemistry department in UNIGE's Science faculty, has been working on a model system that acts like the macrophages in our immune system: the social amoeba Dictyostelium, a unicellular microorganism.

The goal is to find new ways to tackle the disease, which requires a thorough understanding of how the bacterium, known as Mycobacterium tuberculosis, behaves once it takes hold of the macrophages in our lungs.

Immunologist Sandrine Henri of the Immunology Center of Marseille - Luminy, in France, and colleagues tattooed mice tails with green ink to see how waste - disposing macrophages in the skin would respond.

These animals also had fewer macrophages in their livers as well as less fibrosis.

What Litvak found is that the MeCP2 gene is responsible for establishing a threshold for the activation of macrophages in the presence of stimuli and stressors such as hypoxia, corticosteroids and inflammation.

«Results also identified mechanisms regulating the numbers and phenotype of macrophages in the tiny air sacs of the lungs (called alveoli) in health and disease,» said Takuji Suzuki, MD, PhD, the study's first author and a scientist in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's.

«Virus attachment to Clara cells in the bronchioles and pneumocytes and macrophages in the alveoli correlates with high virulence.»

We show here that acidic mammalian chitinase (AMCase) is induced via a T helper - 2 (Th2)-- specific, interleukin - 13 (IL - 13)-- mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.

Furthermore, these results also have an important prognostic value — the positioning of macrophages in hypoxic tumor regions would be an indication of a poor prognosis, while the localization of macrophages in normoxic regions of the tumor could predict a better disease outcome.

The research team, Heller says, has already begun experiments to further explore the implications of these results, which include looking at differences in this pathway between cells taken from allergic and healthy individuals, and testing the efficacy of an inhalable drug that mimics the function of GRB1 and p70S6K to shut off the development of M2 macrophages in the lungs of mice.

In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cells.

Asthma has been correlated with an overabundance of one type of immune cell called M2 macrophages in the lungs.

For the research, the scientists used the platform to target colon macrophages in order to reduce inflammatory symptoms caused by Inflammatory Bowel Disease (IBD) in mouse models.

The sex - specific differences — the smaller hippocampus, the presence of fewer nerve cells, the existence of immune system macrophages in places they shouldn't be — were also found in adulthood.