Sentences with phrase «macrophages with»

Tissue overgrowth (hyperplasia), either of lymphoid cells or macrophages with fibrous tissue (fibrohistiocytic nodules) is also common.

To explore this possibility in the new work, the researchers will culture healthy dog macrophages with osteosarcoma cells to find out whether it leads macrophages to shift gears in the expected way.

(E) Intracellular (internalized) and extracellular bacteria (cell - free culture media) were quantified at 1 h after ex vivo infection of alveolar macrophages with an MOI of 20.

By infecting susceptible mouse macrophages with S. Typhimurium and using global proteomics to analyze the proteins at various time points following infection, researchers identified 1,006 macrophage proteins.

Not exact matches

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

All of the untreated fish with fewer macrophages died within 72 hours of receiving S. flexneri, the researchers reported in December in Current Biology.

Soluble CD14 levels were inversely correlated with measures of bone mineral content and density, suggesting macrophage activation as a possible mechanism for such bone loss.

In the bone, macrophages take the form of osteoclasts — the cells responsible for the resorptive processes associated with continuous bone remodeling.

Then they injected the mice with macrophages lacking a surface protein called TLR4.

This is due to a randomised trial with 215 eligible patients performed between 1989 and 1991, which showed a significant increase in severe thrombocytopenia, severe anemia, pulmonary complications and toxic deaths when granulocyte - macrophage CSFs (GM - CSFs) were used during concurrent chemo - radiotherapy.

Macrophages were dry - fractured by touching the cell surface with cellophane tape after critical point drying to reveal intracellular bacteria.

When macrophages are stimulated with an endotoxin, they produce a factor or factors, termed cachectin, that inhibits the activity of fat - producing (lipogenic) enzymes in cultured adipocytes.

But unlike the normal mice, those with altered macrophages showed no signs of inflammation, such as changes in insulin production, high levels of immune chemicals, and macrophages in their belly fat.

«We came up with a list of potential cellular candidates that could be compensating for the loss of these specific macrophages and used several different tests to determine which cells were clearing away the nerve debris after injury,» Lindborg said.

Plaque formation accelerated in the models transplanted with Tet2 - deficient bone marrow cells, likely through increasing macrophage - driven inflammation in the artery wall.

Asthma has been correlated with an overabundance of one type of immune cell called M2 macrophages in the lungs.

«One of the advantages of working with lung macrophages is that they are one of the first cells that see anything that gets put in an inhaler,» says Heller.

These images show a reduction in the number of macrophages infiltrating atherosclerotic plaques (in green) in animals treated with the IRE1 inhibitor.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

Dr Evanna Mills, who, with Dylan Ryan was joint first author of the work, said: «The macrophage takes the nutrient glucose, whose day job it is to provide energy, and surprisingly turns it into itaconate.

By targeting this switch with tiny molecules, researchers could deny the macrophages calcium and prevent inflammation — even in the brain.

In mice with pancreatic tumors, Kalbasi and other members of the team found relatively high levels of inflammatory compounds including CCL2, the signaling molecule that activates CCR2 on monocytes and macrophages to make these cells migrate to tumors.

By contrast, when the team treated the mice with radiation plus a CCL2 - blocking antibody, the tumors» recruitment of monocytes and macrophages was sharply reduced, and the tumor growth was slowed more dramatically.

An early - stage clinical study by another institution, published in the Lancet Oncology in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.

They first showed that mice with severed sensory nerves produce excessive BH4, churned out both by the injured nerve cells themselves and by macrophages — immune cells that infiltrate damaged nerves and inflamed tissue.

«Tattoo removal can be likely improved by combining laser surgery with the transient ablation of the macrophages present in the tattoo area,» says Malissen.

«Virus attachment to Clara cells in the bronchioles and pneumocytes and macrophages in the alveoli correlates with high virulence.»

Fusin acted preferentially for T cell line - tropic isolates, in comparison to its activity with macrophage - tropic HIV - 1 isolates.

The experiments, including studies conducted in a bioengineered 3 - D model of lung tissue seeded with relevant cells, showed that CHI3L1 regulates a pathway that recruits cells such as macrophages and fibroblasts that produce the scarring, or fibrosis.

Because all the itchy mice had a defective version of the E3 ligase, Copeland suspects that their ubiquitin systems fail to tag immune - related defense proteins or foreign substances called antigens for disposal — both of which then might pile up and attract too many helper macrophages to the scene, wreaking havoc with the immune response.

When mice bearing pancreatic tumors were injected with an antibody that prevents galectin - 9 from docking into dectin - 1, they developed M1 macrophages, which sent signals that dramatically increased the number of T cells capable of attacking the cancer cells.

«Our findings support the concept of pulmonary macrophage transplantation (PMT) as the first specific therapy for children with hPAP»

In the first, principal investigator Glass and colleagues investigated a pair of related transcriptional repressors called Rev - Erb - alpha and Rev - Erb - beta (proteins with important roles in regulating the circadian rhythm in many cell types) in mouse macrophages.

Giving mice an antibody that neutralizes Metrnl left them with a defective response to the cold; they failed to activate the macrophage genes needed to brown their fat.

«We could do this two ways — by depleting the macrophages or by treating the transformed cells with a blocking antibody that shuts down ICAM - 1,» says Dr. Storz.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

Consistent with the San Francisco team's work, Metrnl increased the numbers of certain types of macrophages and the amount of IL - 4 in the fat tissue.

According to Prof. Shaked, the drug caused inflammatory cells (macrophages) in the bone marrow to enhance the aggressiveness of the disease and provide the cancer cells with resistance to treatment.

In mice engineered so their macrophage cells would mimic those of people, expressing the human SIRPα protein, nanoparticles tagged with the CD47 peptide passports stuck around in the circulation rather than being gobbled up.

Amastigotes with such compromised mitochondrial function were unable to multiply in mouse macrophages (i.e. mammalian Leishmania target cells), suggesting that inhibition of LMIT1 can abolish parasite virulence.

They will study human macrophages and dendritic cells isolated from IBD patients with defective GM - CSF function, «The approach represents a step forward in personalizing how we treat patients with IBD,» said Dr. Colombel.

Macrophages without CCR2 originate in the heart; those with CCR2 come from the bone marrow, the research showed.

They also filled the tablet with GMC - SF (granulocyte macrophage colony - stimulating factor), an inflammatory protein known to attract immune cells.

The study's researchers infected macrophages, a type of human white blood cell, with a highly virulent strain of tuberculosis.

Immunologist Sandrine Henri of the Immunology Center of Marseille - Luminy, in France, and colleagues tattooed mice tails with green ink to see how waste - disposing macrophages in the skin would respond.

TAIL TATS When researchers tattooed mouse tails, the only cells found with ink inside were macrophages.

With that in mind, the researchers thought that controlling this protein might revitalize macrophage - based cell therapies.

Ongoing studies from the Discher lab are focused on finding that sweet spot with additional tumor models, as well as on how to engineer macrophages for longer - lasting effect.

The Discher Lab has since shown that a protein on human cells called CD47 functions as a «marker of self» by interacting with a protein on the surface of macrophages called SIRPA.

The Discher lab has expertise with mimicking these protective mechanisms on healthy cells, but now they are targeting the proteins on macrophages that respond to those signals.