The team also showed that the cellular
process macropinocytosis, which participates in cell scavenging nutrients and vesicles, contributes to exosomes uptake in cancer cells with mutant KRAS.
Further study is needed to gain a better understanding about whether exosomes entering cells
via macropinocytosis have other features that could enhance their anti-tumor capabilities.»
«The increased number of exosomes reaching the pancreas may gain further advantage to enter KRAS - associated cancer cells as a result of
enhanced macropinocytosis, which concurs with previous findings,» said Kamerkar.
The main emphasis is to study how cancer cells reprogram their metabolism and protein homeostasis to survive nutrient stress conditions associated to tumor progression and how they might use processes such as autophagy and
macropinocytosis to prevent various forms of cell death, including apoptosis and necrosis, and to keep growing.